Delay of gonadotropin stimulation in patients receiving gonadotropin-releasing hormone agonist (GnRH-a) therapy permits increased clinic efficiency and may enhance in vitro fertilization (IVF) pregnancy rates

Fertility and Sterility
M A DamarioZ Rosenwaks

Abstract

To promote an even temporal distribution of patients starting IVF cycles at our center, patients undergoing GnRH agonist (GnRH-a) suppression frequently delay the start of gonadotropin stimulation. Our objective was to analyze the effect that the delay of initiation of gonadotropin stimulation has on outcome parameters in this population. Retrospective analysis. A tertiary referral reproductive medicine unit. Patients undergoing IVF cycles on long GnRH-a protocols. Patients were treated with either a "standard-dose" or "low-dose" leuprolide acetate protocol initiated in the mid-luteal phase. Delay time, clinical pregnancy rate, ongoing pregnancy rate, cancellation rate. Analysis of the overall group revealed associations between stimulation delay and decreases in stimulation duration and the number of gonadotropin ampules administered. Weighted linear regression analyzes revealed statistically positive relationships between delay time and both clinical pregnancy rates and ongoing pregnancy rates, despite a positive relationship between delay time and cancellation rates. Analysis of the standard-dose and low-dose subgroups revealed that the enhancement of pregnancy rates was attributable primarily to patients in the standard-dos...Continue Reading

Associated Clinical Trials

Citations

Jun 17, 2000·Fertility and Sterility·B A Lessey
Mar 7, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Y YamashitaM Ueki
Feb 21, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sozos J Fasouliotis, Joseph G Schenker
Jun 9, 2001·Current Opinion in Obstetrics & Gynecology·N G Mahutte, A Arici
Jun 21, 2013·Reproductive Biology and Endocrinology : RB&E·Christine DecanterDidier Dewailly
Jul 20, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Haiyan LinDongzi Yang
Jul 19, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Lionel DessollePaul Barrière
Jun 1, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Talha Al-ShawafGedis Grudzinskas

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