PMID: 9538630Apr 16, 1998Paper

Delayed activation-induced T lymphocytes death in aplastic anemia: related with abnormal Fas system

The Korean Journal of Internal Medicine
S C KimY W Ko

Abstract

To quantitate apoptosis and Fas antigen expression of T lymphocytes by activation in aplastic anemia (AA) and compare with that of normal controls and completely-recovered AA, and to investigate the apoptotic sensitivity to anti-fas antibody of activated T lymphocytes in AA. We studied the expression of Fas antigen on fresh T lymphocytes of twenty patients with AA [13 newly diagnosed, 7 recorvered AA after immunosuppressive therapy (IST)], and investigated the activation-induced cell death (AICD) and Fas expression by activation [interleukin-2 (200 U/ml) and phytohemagglutinin (50 micrograms/ml)] in 5 newly-diagnosed AA, 5 normal controls and 5 AA in complete response (CR). Apoptotic sensitivity to anti-Fas antibody was assessed by the time-course kinetics of induction of cell death by anti-Fas antibody (500 ng/ml). There was no significant difference of Fas antigen expression on freshly-isolated T lymphocytes among newly-diagnosed severe AA, normal controls and patients with AA in CR after IST. In normal controls, T lymphocytes death was greatly increased at 3 days of activation, and Fas antigen expression on T lymphocytes was increased above baseline at day 1 of activation. In contrast, in newly-diagnosed AA, T lymphocytes sh...Continue Reading

References

Dec 1, 1989·The Journal of Experimental Medicine·P A SingerA N Theofilopoulos
Jan 1, 1995·Immunology Today·S Nagata, T Suda
Sep 1, 1995·British Journal of Haematology·J P MaciejewskiN S Young
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M AdachiS Nagata
Oct 1, 1994·The Journal of Clinical Investigation·R A GottliebR L Engler
Jul 1, 1993·Immunology Today·D KabelitzK Pechhold

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Citations

Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephanie O OmokaroNeal S Young

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