Delayed administration IL-1β neutralizing antibody improves cognitive function after transient global ischemia in rats
Abstract
In order to study the protective effects on motor and cognitive function by inhibiting IL-1β as delayed as 24h after global ischemia, we designed behavioral testing protocol and histology detection after 10 min transient global ischemia followed by IL-1β or its antibody intracerebroventricular injection. We found benefit of IL-1β antibody treatment 24h after ischemia in cognitive function recovery. But no obvious amelioration in motor function was found. Further we detected cell morphology and survival by histology staining and proved IL-1β antibody could reduce ischemia induced cell morphological changes and cell loss in hippocampus, which related with cognitive function. Present results indicate intervening IL-1β pathway could be helpful in cognitive function recovery even as late as 24h after ischemia happens.
References
Cortical protection by localized striatal injection of IL-1ra following cerebral ischemia in the rat
Citations
Related Concepts
Related Feeds
Astrocytes
Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.