Abstract
In search of animal models suitable for investigating myelin repair, we have analysed myelinogenesis in a transgenic mouse mutant with delayed myelination, but with a normal life-span. The 2-50 mutant which carries a c-myc gene under the regulation of the myelin basic protein promoter has been described previously (Orian et al.: J Neurosci Res 39:604-612, 1994). Here we show that appropriate mRNA transcripts and their corresponding protein products are generated, but that the accumulation of these products is delayed in transgenic mice with respect to nontransgenic littermates. This phenomenon is associated with aberrant myelin and paucity of normal oligodendrocytes. Myelination appears to be carried out by abnormal, oligodendrocyte-like cells. We propose that the primary defect in the 2-50 mutant is an inability to generate the normal number of mature oligodendrocytes. This mutant represents a novel class of mutant in which oligodendrocyte development and myelination can be studied in the absence of interference with a gene for a structural protein of myelin, in an animal with normal survival. It may also represent a new tool to investigate in vivo gliogenesis and regulatory events bringing about the coordinated regulation of ...Continue Reading
References
May 1, 1992·Journal of Neurochemistry·P AmiguetJ M Matthieu
Jan 1, 1991·Annual Review of Neuroscience·K MikoshibaK Ikenaka
Jan 1, 1991·Developmental Neuroscience·N Kerlero de RosboC C Bernard
Aug 1, 1985·Cell·A RoachL Hood
Feb 27, 1987·Cell·C ReadheadL Hood
Nov 2, 1987·FEBS Letters·W B MacklinK Kampf
Dec 1, 1987·Journal of Neurochemistry·K A NaveR J Milner
Jul 29, 1988·Science·M KatsukiT Nomura
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M KimuraM Katsuki
Jan 1, 1988·Molecular Neurobiology·A T Campagnoni, W B Macklin
Jan 1, 1969·The Journal of Comparative Neurology·S Mori, C P Leblond
May 1, 1970·The Journal of Comparative Neurology·S Mori, C P Leblond
Oct 1, 1969·The Journal of Comparative Neurology·S Mori, C P Leblond
Apr 1, 1983·Developmental Biology·J H CarsonE Barbarese
Jul 1, 1980·Journal of Neurobiology·A T Campagnoni, M J Hunkeler
Mar 1, 1994·Neuron·C ReadheadK A Nave
Sep 1, 1994·Journal of Neurochemistry·N L NadonL D Hudson
Aug 1, 1994·Neuron·T KagawaK Mikoshiba
Dec 1, 1994·Journal of Neuroscience Research·J M OrianM F Gonzales
Jan 1, 1995·Developmental Neuroscience·K Ikenaka, T Kagawa
Citations
Sep 1, 2009·ASN Neuro·Erin C JacobsAnthony T Campagnoni
Feb 8, 2014·Neuroscience·L MagriP Casaccia
Oct 13, 2001·Journal of Neuroscience Research·J M OrianR Reynolds
Mar 29, 2001·Microscopy Research and Technique·M OnukiJ M Orian