Delayed and short course of rapamycin prevents organ rejection after allogeneic liver transplantation in rats

World Journal of Gastroenterology : WJG
Salim HamdaniCaroline Pilon

Abstract

To test whether a delayed and short course of rapamycin would induce immunosuppressive effects following allogeneic orthotopic liver transplantation (OLT) in rats. Allogeneic OLTs were performed using Dark Agouti livers transplanted into Lewis recipients, and syngeneic OLTs were performed using the Lewis rat strain. Rapamycin (1 mg/kg per day) was administered by gavage from day 4 to day 11 post-transplantation. Lymphocyte cellular compartments were analyzed by flow cytometry in draining lymph nodes, non-draining lymph nodes and the spleen at days 11 and 42 in rapamycin-treated rats, untreated control rats and syngeneic grafted rats. Skin grafts from Dark agouti or from F344 RT were performed at day 30 on liver grafted rats treated with rapamycin. An 8-d course of rapamycin treatment initiated 4 d following transplantation resulted in the survival of grafted rats for more than 100 d. In contrast, untreated rats died of liver failure within 13 to 21 d. The analysis of the cellular compartment revealed an increase in two cellular subpopulations, specifically myeloid-derived suppressor cells (MDSCs) and CD8+CD45RClow T cells, without major modifications in the regulatory T cell (Treg) compartment in treated rats in the early stage...Continue Reading

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Citations

May 12, 2020·Human Molecular Genetics·Kayalvizhi MadhivananR Claudio Aguilar
Mar 22, 2019·Frontiers in Immunology·Jordi OchandoEstela Paz-Artal
Dec 12, 2018·Frontiers in Physiology·Rosanna SalviaPatrizia Falabella
Mar 10, 2021·Journal of Tissue Engineering and Regenerative Medicine·Hai LiuDaozhang Cai
Jan 9, 2021·Transplantation·Xinle WangCatia T Perciani

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