Abstract
The concept of antibody dependent enhancement (ADE) of dengue virus (DENV) infection is a cornerstone of our current understanding of dengue pathogenesis, although some questions as to the mechanism remain, particularly in regards to the behavior of low and high passage virus isolates. This study utilized two low passage DENV 4 isolates and a laboratory adapted DENV 4 isolate to investigate the potential of low passage isolates to undergo ADE. Little or no ADE of infection was observed on day 2 post infection with low passage isolates, while high enhancement of infection was seen with the laboratory adapted virus. However, both of the low passage isolates showed high levels of infection (60-100%) by day 5 post infection. These results show that low passage DENV 4 viruses undergo ADE mediated infection, but that the process is significantly temporally delayed as compared to laboratory adapted DENV 4.
References
Jul 1, 1977·The Journal of Experimental Medicine·S B Halstead, E J O'Rourke
Feb 1, 1990·The American Journal of Tropical Medicine and Hygiene·M G GuzmánL Morier
May 1, 1989·Reviews of Infectious Diseases·S B Halstead
Jul 1, 1980·The American Journal of Tropical Medicine and Hygiene·S B HalsteadE J O'Rourke
Jul 1, 1982·The American Journal of Tropical Medicine and Hygiene·E A HenchalW E Brandt
Nov 1, 1984·American Journal of Epidemiology·N SangkawibhaS B Halstead
Sep 1, 1994·The Journal of General Virology·M A O'Sullivan, H M Killen
Jul 17, 1998·Clinical Microbiology Reviews·D J Gubler
Oct 14, 2003·Journal of Medical Virology·Patchima SithisarnDuncan R Smith
Oct 6, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Sutee YoksanNuananong Jirakanjanakit
Feb 18, 2010·The Journal of Infectious Diseases·Sukathida UbolNaphak Modhiran
Oct 5, 2010·The Lancet Infectious Diseases·Scott B HalsteadDavid M Mosser
Nov 5, 2010·Virology·Pathama KlompornDuncan R Smith
Feb 3, 2012·PloS One·Nitwara WikanDuncan R Smith
Aug 4, 2012·PLoS Neglected Tropical Diseases·Arunee SabchareonG William Letson
Apr 9, 2013·Nature·Samir BhattSimon I Hay
May 17, 2013·Journal of Virology·S V ScherbikM A Brinton
Mar 20, 2014·PloS One·Panjaporn ChaichanaKazuyoshi Ikuta