Delayed bipolar and ganglion cells neuroretinal processing in regular cannabis users: The retina as a relevant site to investigate brain synaptic transmission dysfunctions

Journal of Psychiatric Research
Thomas SchwitzerVincent Laprevote

Abstract

Cannabis use is widespread worldwide, but the impact of smoking cannabis regularly on brain synaptic transmission has only been partially elucidated. The retina is considered as an easy means of determining dysfunction in brain synaptic transmission. The endocannabinoid system is involved in regulating retinal synaptic transmission, which might also be affected by tobacco. Previous preliminary results have shown impairments in retinal ganglion cell response in cannabis users. Here, we test the extent to which earlier retinal levels-bipolar cells and photoreceptors-are affected in cannabis users, i.e. by the association of tobacco and cannabis. We recorded pattern (PERG) and flash (fERG) ERG in 53 regular cannabis users and 29 healthy controls. Amplitude and peak time of P50 and N95 (PERG) and of a- and b-waves (fERG) were evaluated. Cannabis users showed a significant increase in PERG N95 peak time and in fERG light-adapted 3.0 b-wave peak time, compared with controls (p = 0.0001 and p = 0.002, respectively; Mann-Whitney U test). No significant difference was found between the groups in terms of wave amplitude (p = 0.525 and p = 0.767 for the N95 and light-adapted 3.0 b-wave amplitude respectively; Mann-Whitney U test). The res...Continue Reading

Citations

Aug 30, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ludovic PolliThomas Schwitzer
Nov 12, 2019·Schizophrenia Research·Steven M SilversteinDocia L Demmin
Aug 9, 2020·Survey of Ophthalmology·Michael T M Wang, Helen V Danesh-Meyer
Feb 27, 2021·Journal of Psychiatric Research·Mathilde DartoisThomas Schwitzer
Feb 19, 2019·Neuroscience and Biobehavioral Reviews·Thomas SchwitzerVincent Laprevote
Jul 30, 2019·Schizophrenia Research·Florent BernardinVincent Laprevote

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