Delayed blood pressure recovery ratio and its relation to endothelial function and left ventricular diastolic function in prediabetics

Echocardiography
Ragab A MahfouzMohamed Goda

Abstract

Endothelial function plays a key role in determining the clinical manifestations of established atherosclerotic lesions and has shown to be associated with suppressed sympathetic tone. Abnormal heart rate recovery (HRR) and systolic blood pressure (SBP) response during recovery has been found to have diagnostic role for detecting cardiovascular risk. To investigate whether with abnormal HRR and delayed SBP recovery ratio after exercise could predict endothelial dysfunction in prediabetic subjects. Ninety-two prediabetic patients underwent brachial artery flow-mediated dilatation (FMD) test and a maximal exercise stress test. Seventy-eight healthy subjects served as a control group. HRR at 1 minute (HRR1 ) and SBP recovery ratio (SBPRR3 ) was defined as the SBP at minute 3 of recovery divided by SBP at peak exercise. Left ventricular diastolic function was assessed utilizing both conventional and tissue Doppler echocardiography. Flow-mediated dilatation was significantly decreased in prediabetics versus controls (P < 0.0001). Isovolumetric relaxation time and E/E' were significantly increased in prediabetics (P < 0.01 and <0.001). Delayed SBPRR3 was significantly correlated with impaired endothelial function and (E/E') in predia...Continue Reading

References

Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Sep 1, 1993·Journal of the American College of Cardiology·M HashimotoG Kajiyama
Jul 10, 1999·Journal of the American College of Cardiology·H KawanoH Yasue
Aug 11, 1999·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·M AlamR Nordlander
Jan 15, 2002·Journal of the American College of Cardiology·Mary C CorrettiUNKNOWN International Brachial Artery Reactivity Task Force
Oct 3, 2003·Journal of the American College of Cardiology·Michael E WidlanskyJoseph A Vita
Nov 23, 2005·Neurology·Elizabeth R VogelPhillip A Low
Mar 1, 2006·Cardiovascular Diabetology·Ricardo J EsperRogelio A Machado
Feb 21, 2008·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·G D XiangL Xu
Mar 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Takuro KubozonoLong Tai Fu
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Nov 28, 2012·Journal of cardiology·Haruki ItohUNKNOWN Committee on Exercise Prescription for Patients (CEPP) Members

❮ Previous
Next ❯

Citations

May 15, 2015·Scandinavian Cardiovascular Journal : SCJ·Asli TanindiHasan Fehmi Tore
Mar 20, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Jordan LoaderMatthieu Roustit

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.