Delayed blood transfusion is associated with mortality following radical cystectomy.

Scandinavian Journal of Urology
Wei Shen TanMatthew Mossanen

Abstract

Objectives: To examine the temporal association between blood transfusion and 90-day mortality in patients with bladder cancer treated with radical cystectomy.Methods: This represents a retrospective cohort study of patients treated with radical cystectomy within the Premier Hospital network between 2003 and 2015. Patients outcomes were stratified those who received early blood transfusion (day of surgery) vs delayed blood transfusion (postoperative day ≥1) during the index admission. Primary end point was 90-day mortality following surgery.Results: The median age of 12,056 patients identified was 70 years. A total of 7,201 (59.7%) patients received blood transfusion. Within 90 days following surgery, 57 (2.2%), 162 (5.9%) and 123 (6.7%) patients in the early, delayed and both early and delayed transfused patients died respectively. Following multivariate logistic regression to account for patient (age and Charlson Comorbidity Index [CCI]) and hospital (surgeon volume, surgical approach and academic status) factors, delayed blood transfusion was independently associated with 90-day mortality (Odds ratio [OR], 2.64; 95% Confidence Interval [CI], 1.98-3.53; p < 0.001). A sensitivity analysis defining early blood transfusion as <2...Continue Reading

References

Jan 23, 1998·JAMA : the Journal of the American Medical Association·J L CarsonB L Strom
Sep 24, 2002·JAMA : the Journal of the American Medical Association·Jean Louis VincentUNKNOWN ABC (Anemia and Blood Transfusion in Critical Care) Investigators
Jul 27, 2007·Best Practice & Research. Clinical Anaesthesiology·Aryeh ShanderDonat R Spahn
Dec 24, 2015·Advances in Urology·Wei Shen TanJohn D Kelly
Oct 13, 2016·JAMA : the Journal of the American Medical Association·Jeffrey L CarsonAaron A R Tobian
Sep 5, 2017·European Urology·Matthew Mossanen, Mark A Preston
Nov 14, 2017·The New England Journal of Medicine·C David MazerUNKNOWN TRICS Investigators and Perioperative Anesthesia Clinical Trials Group
Feb 1, 2018·Transfusion·Kenneth E RemyUNKNOWN Pediatric Critical Care Blood Research Network (Blood Net)

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