PMID: 2496891Apr 10, 1989Paper

Delayed c-fos proto-oncogene expression in the rat hippocampus induced by transient global cerebral ischemia: an in situ hybridization study

Brain Research
M B JørgensenD R Gehlert

Abstract

The relative levels of c-fos mRNA in individual neurons of the hippocampal formation of rats is dramatically increased following 20 min of cerebral ischemia induced by 4-vessel occlusion. After 24 h of recirculation, a number of scattered neurons in the dentate hilus became hybridization positive. This effect appeared to peak between 24 and 48 h. A few neurons in the pyramidal cell layer of CA1 expressed c-fos as early as 24 h, but the most intense labeling in this region was seen at 72 h of recirculation. These results correlate well with the known distribution of delayed ischemic necrosis in the brain.

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Citations

May 20, 1998·Journal of Molecular Neuroscience : MN·A S HazellA M Hakim
Jan 1, 1993·Journal of Molecular Neuroscience : MN·S S SchreiberM Baudry
Jan 1, 1990·Cancer Chemotherapy and Pharmacology·H M SchipperE Wang
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Feb 17, 1992·Neuroscience Letters·S S SchreiberM Baudry
Jan 1, 1991·Neuroscience·R Schmidt-Kastner, T F Freund

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