Abstract
Previous investigations have demonstrated that early preconditioning induced by nitroglycerin is mediated by calcitonin gene-related peptide (CGRP). In the present study, we addressed the question of whether delayed preconditioning induced by nitroglycerin in the rat is related to stimulation of the release and synthesis of CGRP. Sprague-Dawley rats were pretreated with nitroglycerin 24 h before the experiment. The left main coronary artery was occluded for 60 min, followed by 3 h reperfusion. Infarct size, serum creatine kinase activity, serum levels of NO and CGRP and the expression of alpha- and beta-CGRP isoform mRNA in lumbar dorsal root ganglia were measured. Pretreatment with nitroglycerin (60 or 120 microg/kg i.v.) reduced both the infarct size and the release of creatine kinase during reperfusion and caused a significant increase in the expression of alpha-CGRP mRNA, but not beta-CGRP mRNA, concomitantly with an increase in concentrations of NO and CGRP. The increase in CGRP expression preceded the increase in CGRP release. The effects of nitroglycerin were abolished completely by pretreatment with methylene blue (30 mg/kg i.p.), an inhibitor of guanylate cyclase, or capsaicin (50 mg/kg s.c.), which selectively deplete...Continue Reading
Citations
Dec 25, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Petra HartmannAndrea Szabó
Apr 14, 2006·Basic Research in Cardiology·Efstathios K IliodromitisDimitrios Th Kremastinos
Nov 13, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jie LiYibin Hao
Jul 26, 2002·Regulatory Peptides·Chang Ping HuYuan Jian Li
May 24, 2003·Regulatory Peptides·Chang-Ping HuYuan-Jian Li
Jul 2, 2003·Regulatory Peptides·Pan-Yue DengYuan-Jian Li
Jan 20, 2004·International Journal of Cardiology·Yan-Hua DuYuan-Jian Li
Apr 25, 2003·Medical Hypotheses·Yuan Jian Li, Yan Hua Du
Apr 15, 2014·European Journal of Pharmacology·Antonia StefaniotouTheodoros Xanthos
Jan 2, 2008·Regulatory Peptides·Dai LiYuan-Jian Li
Feb 14, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Saurabh GuptaAntoinette MaassenVanDenBrink
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·Jian-Hua ZhangZheng Wu
Sep 11, 2008·European Journal of Pharmacology·Qing-Quan ChenYuan-Jian Li
Jul 1, 2008·International Journal of Cardiology·Babak BaharvandAli Asghar Kiani
Jul 16, 2013·Headache·Marcelo E BigalAlan M Rapoport
Oct 7, 2004·European Journal of Pharmacology·Dan LuoYuan-Jian Li
May 4, 2004·Regulatory Peptides·Pan-Yue DengYuan-Jian Li
Mar 26, 2014·Cephalalgia : an International Journal of Headache·Marcelo E BigalRafael Escandon
Jul 23, 2004·Physiological Reviews·Susan D Brain, Andrew D Grant
Aug 18, 2004·Journal of Hypertension·Pan-Yue DengYuan-Jian Li
Sep 7, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Kazuhiro KamadaRonald J Korthuis
Nov 14, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Taiji YamaguchiRonald J Korthuis
Sep 11, 2019·Cardiovascular Research·Wenqun LiYuanjian Li
Feb 26, 2014·Journal of Cardiovascular Pharmacology·Xiao-Juan Sun, Shan-Shan Pan
Jun 3, 2018·Basic Research in Cardiology·Marina V BasalayDerek M Yellon