Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen

American Journal of Physiology. Heart and Circulatory Physiology
Yang ShiJohn E Baker

Abstract

We determined whether isoflurane can confer delayed cardioprotection in the adult rat by triggering increased production of reactive oxygen (ROS) and nitrogen species (RNS). Our objectives were to determine 1) the concentration of isoflurane that confers delayed cardioprotection in the adult rat, 2) the role of ROS and RNS in the induction of delayed cardioprotection, and 3) the cellular sources of ROS and RNS responsible for induction of delayed cardioprotection by isoflurane. Male Sprague-Dawley rats at 8 wk of age (n = 8 rats/group) were exposed to 0.5%, 0.8%, 1%, and 2% (vol/vol) isoflurane-100% oxygen for 2 h. Isoflurane conferred delayed cardioprotection 24 h later at a concentration of 0.8% (vol/vol). Administration of manganese (III) tetrakis (4-benzoic acid)porphyrin chloride (MnTBAP), a superoxide scavenger (15 mg/kg ip), or N(G)-nitro-L-arginine methyl ester (L-NAME), a general nitric oxide synthase inhibitor (15 mg/kg ip), 15 min before isoflurane treatment abolished the delayed cardioprotective effects of isoflurane. MnTBAP and L-NAME had no effect on delayed cardioprotection in untreated hearts. Perfusion of isolated hearts with hydroethidine, a fluorescent probe for superoxide, after isoflurane treatment resulted...Continue Reading

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Citations

Mar 24, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Marie HauerslevMichael Rahbek Schmidt
Aug 25, 2007·Anesthesia and Analgesia·Eliana LucchinettiMichael Zaugg
Nov 21, 2008·Anesthesia and Analgesia·Nina C WeberBenedikt Preckel
Jan 30, 2008·Anesthesia and Analgesia·Ge LiangHuafeng Wei
Jul 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Mayu Wakeno-TakahashiKoh Shingu
Nov 27, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Paul S Pagel, Judith A Hudetz

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