PMID: 11914106Mar 27, 2002Paper

Delayed cardioprotective effects of exercise in dogs are aminoguanidine sensitive: possible involvement of nitric oxide

Clinical Science
László BabaiA Vegh

Abstract

Dogs were subjected to exercise on a treadmill, using a protocol in which the speed and slope were increased every 3 min, and which elevated both heart rate (to a mean of 198+/-14 beats.min(-1)) and mean arterial blood pressure (to 150+/-4 mmHg). Then, 24 or 48 h later, the dogs were anaesthetized with a mixture of alpha-chloralose and urethane and subjected to a 25 min occlusion of the left anterior descending coronary artery. The control dogs (instrumented but not exercised) were subjected to the same procedure. In some dogs the nitric oxide synthase inhibitor aminoguanidine (50 mg.kg(-1); intravenous) was administered 30 min before occlusion. Baroreflex sensitivity (BRS) was determined by the rapid bolus injection of phenylephrine 60 min before, and again 3 min after, the onset of occlusion. Exercise markedly reduced the consequences of coronary artery occlusion 24 h (but not 48 h) later, without modifying myocardial tissue blood flow. In the exercised dogs there were reductions in arrhythmia severity [ventricular fibrillation (VF) during occlusion, 0%; survival from the combined ischaemia/reperfusion insult, 70%] compared with controls (VF during occlusion, 36%; survival, 9%). BRS was preserved during occlusion in the exerc...Continue Reading

Citations

May 4, 2010·American Journal of Physiology. Heart and Circulatory Physiology·John C QuindryEmily Hoyt
Nov 2, 2011·Biological & Pharmaceutical Bulletin·Yusuke TakizawaMasahiro Hayashi
Mar 16, 2011·Cardiology Research and Practice·Saeid Golbidi, Ismail Laher
Sep 15, 2004·European Journal of Pharmacology·Orsolya NagyAgnes Végh
Sep 30, 2004·Free Radical Biology & Medicine·Karyn L HamiltonScott K Powers
Dec 18, 2015·Dose-response : a Publication of International Hormesis Society·Rick J AllemanDavid A Brown
Sep 28, 2012·Molecular and Cellular Biochemistry·Mária KovácsAgnes Végh
May 7, 2013·Journal of Cardiovascular Pharmacology·Brock T JensenReid Hayward
Feb 18, 2009·Macromolecular Rapid Communications·Cong Duan VoNicola Tirelli
Jun 19, 2013·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Claudio Garino, Luca Salassa

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