PMID: 7542534Mar 1, 1995Paper

Delayed circulatory failure due to the induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in anaesthetized rats

British Journal of Pharmacology
S J De KimpeJ Vane

Abstract

1. This study investigates the effect of lipoteichoic acid (LTA) from the cell wall of Staphylococcus aureus, a micro-organism without endotoxin, on haemodynamics and induction of nitric oxide synthase (iNOS) in the anaesthetized rat. 2. Intravenous injection of LTA (10 mg kg-1) resulted in a decrease in blood pressure from 123 +/- 1 mmHg to 83 +/- 7 mmHg after 270 min (P < 0.001) and a reduction of the pressor response to noradrenaline (1 microgram kg-1) from 33 +/- 1 mmHg.min to 23 +/- 3 mmHg.min after 270 min (P < 0.05). 3. The delayed circulatory failure (hypotension and vascular hyporeactivity) caused by LTA was prevented by pretreatment of rats with dexamethasone (10 mg kg-1, 60 min prior to LTA) or the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (L-NMMA, 10 mg kg-1 h-1, i.v. infusion starting 30 min prior to LTA). 4. In contrast, treatment of rats with polymyxin B (0.05 mg kg-1), an agent which binds endotoxin (lipopolysaccharides, LPS), did not affect the delayed circulatory failure caused by LTA. Polymyxin B, however, attenuated the hypotension and vascular hyporeactivity to noradrenaline afforded by endotoxaemia (2 mg kg-1 LPS, i.v.) for 270 min. 5. The delayed circulatory failure caused by LTA was associ...Continue Reading

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Citations

Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·S J De KimpeJ R Vane
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·C ThiemermannJ R Vane
Feb 7, 2001·The Journal of Experimental Medicine·S MorathT Hartung
Aug 31, 2000·Critical Care Medicine·O A StrandK A Kirkebøen
Jan 1, 1996·Microbiology and Immunology·H Maeda
Dec 1, 1996·British Journal of Pharmacology·K M KengatharanC Thiemermann
Sep 18, 2002·Kidney International·Prabal K ChatterjeeChristoph Thiemermann
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Nov 1, 2011·Toxicology and Applied Pharmacology·Irene CuadradoSonsoles Hortelano
May 12, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Takayuki NakamuraHans-Joachim Schäfers
Jun 26, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jeffrey Brinker
May 13, 1999·Biochimica Et Biophysica Acta·M A Titheradge

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