Delayed clamping vs milking of umbilical cord in preterm infants: a randomized controlled trial.

American Journal of Obstetrics and Gynecology
Samantha K ShirkKathleen L Smith

Abstract

It has been established that delayed umbilical cord clamping in preterm infants results in improvement in neonatal anemia, need for transfusion, incidence of necrotizing enterocolitis, and intraventricular hemorrhage by increasing neonatal circulating blood volume. However, the effects of umbilical cord milking as an alternative to delayed clamping in preterm infants are unclear. The primary objective of this study was to compare the effect of delayed clamping vs milking of the umbilical cord on the initial hematocrit concentration in preterm births (23-34 weeks gestation). In addition, we sought to compare the effects of delayed clamping vs milking on the incidences of intraventricular hemorrhage, necrotizing enterocolitis, and need for transfusion (secondary objectives). The study was an unblinded randomized controlled trial of singleton preterm infants who were born 23 weeks 0 days to 34 weeks 6 days gestation and were assigned to 1 of 2 controlled study groups: delayed cord clamping for 60 seconds or milking of the cord towards the infant 4 times before clamping. Randomization occurred via block randomization with an allocation ratio of 1 to 1. The patients' third stage of delivery was standardized for route of delivery and...Continue Reading

Citations

Aug 29, 2020·Pediatric Research·Sheila M GephartMichael S Caplan
Nov 20, 2019·JAMA : the Journal of the American Medical Association·Heike Rabe, Ola Andersson
May 14, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Prashant AgarwalGirija Natarajan
Aug 1, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Neha KumbhatUNKNOWN undefined
Apr 15, 2020·Journal of Clinical Medicine·Inmaculada Ortiz-EsquinasAntonio Hernández-Martínez
Mar 11, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Haribalakrishna BalasubramanianNandkishor Kabra
Mar 1, 2020·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Carlos ZozayaMaría Luz Couce
Jan 9, 2021·The Journal of Pediatrics·Neha KumbhatUNKNOWN Generic Database Subcommittee of the National Institute of Child Health and Human Development Neonatal Research Network
Feb 27, 2021·Pediatrics·Anna Lene SeidlerUNKNOWN INTERNATIONAL LIAISON COMMITTEE ON RESUSCITATION NEONATAL LIFE SUPPORT TASK FORCE

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.