Delayed cognitive deficits can be alleviated by calcium antagonist nimodipine by downregulation of apoptosis following whole brain radiotherapy

Oncology Letters
Jing TongBao-Hua Jiao

Abstract

Radiation therapy is important for the comprehensive treatment of intracranial tumors. However, the molecular mechanisms underlying the pathogenesis of delayed cognitive dysfunction are not well-defined and effective treatments or prevention measures remain insufficient. In the present study, 60 adult male Wistar rats were randomly divided into three groups, which included a control, whole brain radiotherapy (WBRT) (single dose of 30 Gy of WBRT) and nimodipine (single dose of 30 Gy of WBRT followed by nimodipine injection intraperitoneally) groups. The rats were sacrificed 7 days or 3 months following irradiation. At 3 months, the Morris water maze test was used to assess spatial learning and memory function in rats. The results demonstrated that the WBRT group demonstrated a significantly impaired cognitive performance, decreased numbers of hippocampal Cornu Ammonis (CA)1 neurons and upregulated expression of caspase-3 in the dentate gyrus compared with those in the control and nimodipine groups. Reverse transcription-quantitative polymerase chain reaction analysis demonstrated that the WBRT group exhibited increased ratio of B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax)/Bcl-2 compared with that in control and nimodipin...Continue Reading

References

Nov 1, 1995·Stroke; a Journal of Cerebral Circulation·R BullockH F Young
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·A E WestM E Greenberg
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·K A Roth, C D'Sa
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 27, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seth Love
May 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiao-Ming LiTian-Ming Gao
Jul 6, 2007·The European Journal of Neuroscience·Jian ShiSteven G Kernie
Aug 8, 2008·Molecular Neurobiology·P S VoslerJ Chen
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Andrew S NaylorH Georg Kuhn
Oct 19, 2010·Trends in Cognitive Sciences·Dori Derdikman, Edvard I Moser
Jan 23, 2013·Neurological Research·Alexander SemmlerMichael Linnebank
Feb 8, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dana Greene-SchloesserMike E Robbins
Sep 14, 2013·Current Biology : CB·Alison R Preston, Howard Eichenbaum
Nov 1, 2013·International Journal of Molecular Medicine·Hui LiChunli Xie
Nov 28, 2015·International Journal of Molecular Sciences·Sona Balentova, Marian Adamkov
Jun 23, 2016·International Journal of Molecular Sciences·Yu-Qing LiShun Wong
Dec 23, 2016·Frontiers in Molecular Neuroscience·Thomas Preat, Valérie Goguel
Nov 23, 2017·Environmental Health and Preventive Medicine·Yong Kyun Jeon, Chang Ho Ha

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.