Delayed conversion from central venous catheter to non-catheter hemodialysis access associates with an increased risk of death: A retrospective cohort study based on data from a large dialysis provider.

Hemodialysis International
Jochen G RaimannPeter Kotanko

Abstract

Hemodialysis initiation using a central venous catheter (CVC) poses an increased risk of death. Conversion to an arterio-venous graft or fistula (AVF, AVG) improves outcomes. The relationship of primary dialysis access and timing of conversion from CVC to either AVF or AVG to all-cause mortality was investigated. Two retrospective analyses in incident hemodialysis patients commencing treatment from January 2010 to December 2014 in dialysis clinics in the United States were conducted. Analysis 1 stratified as per access at initiation and those commencing with CVC were further stratified into (a) those that had a CVC, AVF, or AVG the entire year; (b) those that were converted to either AVF or AVG within either (i) the first or (ii) the second 6 months. Kaplan Meier analysis and Cox regression analysis were employed. Analysis 2 included all CVC patients investigating the relationship between access conversion time and mortality risk using a Cox proportional hazards model depicting the hazard ratio (HR) as a spline function over time. Two subsets from initial 78,871 patients were studied. In Analysis 1 both AVF (referent) and AVG [HR 1.12 (0.97 to 1.30)] associated with a better outcome than CVC [HR 1.55 (1.38 to 1.74)] during foll...Continue Reading

References

Sep 29, 2001·Kidney International·R K DhingraF K Port
Jul 12, 2002·Kidney International·Stephen PastanWilliam M McClellan
Oct 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jay L XueAllan J Collins
Feb 24, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael AllonSteve J Schwab
Mar 10, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brian D BradburyMahesh Krishnan
Sep 15, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eduardo LacsonRaymond M Hakim
Oct 5, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Eduardo LacsonRaymond M Hakim
Apr 11, 2012·Hemodialysis International·Ranil N DeSilvaAlexander S Goldfarb-Rumyantzev
Feb 2, 2017·Journal of the American Society of Nephrology : JASN·Robert R QuinnPietro Ravani
May 18, 2017·American Journal of Nephrology·Jochen G RaimannUNKNOWN Monitoring Dialysis Outcomes (MONDO) Initiative
May 20, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Rasheeda K HallCathleen S Colón-Emeric
Dec 5, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ronald L PisoniBruce Robinson

❮ Previous
Next ❯

Citations

Jun 17, 2021·International Urology and Nephrology·Jocemir Ronaldo LugonUNKNOWN COVID-19 HD-Brazil Investigators

❮ Previous
Next ❯

Software Mentioned

R Foundation for
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.