Delayed decrease of excitatory amino acid neurotransmitters in parietotemporal cortex and hippocampus after complete cerebral ischemia in aged rats
Abstract
A 15-min period of complete cerebral ischemia (CCI) was used in aged rats to investigate changes in tissue contents of the amino acid neurotransmitters (AANT) glutamate (glu), aspartate (asp), gamma aminobutyric acid (gaba) and glycine (gly) in parietotemporal cortex and hippocampus during ischemia and up to 96 h of postischemic recirculation. The AANT were determined by HPLC. The excitatory AANT glu and asp showed a first decrease at the end of CCI in hippocampus and after 1 h of postischemic recirculation in parietotemporal cortex, reflecting a release of these AANT into the extracellular space with a further loss into the blood. A second decrease in glu and asp was seen after 24 h of postischemic recirculation in hippocampus and after 48 h in parietotemporal cortex. This coincides with previously described disturbances in energy metabolism from 24 h to 96 h in hippocampus and from 48 h to 72 h in parietotemporal cortex in the same experimental model in aged rats. This might be a causal factor in delayed postischemic neuronal damage. A comparison with investigations in young animals reveals an enhanced decrease of glutamate and aspartate tissue contents during the postischemic recirculation period in old rats indicating an en...Continue Reading
References
Release of amino acid neurotransmitters in different cortical areas of conscious adult and aged rats
Citations
Related Feeds
Brain Ischemia
Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.