PMID: 5894227Feb 1, 1965

Delayed dermal hypersensitivity in mice to spherule and mycelial extracts of Coccidioides immitis

Journal of Bacteriology
Y C KongL N Kong

Abstract

Kong, Yi-chi M. (University of California, Berkeley), D. C. Savage, and Leighton N. L. Kong. Delayed dermal hypersensitivity in mice to spherule and mycelial extracts of Coccidioides immitis. J. Bacteriol. 91:876-883. 1966.-A delayed hypersensitivity reaction to spherule and mycelial extracts of Coccidioides immitis was elicited in the footpads of mice vaccinated with killed spherules. Emulsification of the spherules with Freund's adjuvants was unnecessary, but a high concentration of antigen was required to elicit the reaction. Injection of the extracts produced, initially, a swelling which subsided within 4 hr, and then induration, which began at 6 to 8 hr and reached a maximum at 24 hr. The time course of the reaction corresponded to that of the tuberculin reaction in BCG-vaccinated mice. The histological response to coccidioidal extracts was characterized by the early infiltration of both polymorphonuclear and mononuclear cells, and the subsequent predominance of mononuclear cells at 24 to 48 hr. By 72 hr, the mononuclear cells comprised >90% of the cellular infiltrate. Animals infected intranasally with arthrospores (1 to 5 ld(50)) reacted negatively before and during the crisis period; thereafter (by 28 to 31 days after i...Continue Reading

Citations

Aug 10, 2002·Revista Da Sociedade Brasileira De Medicina Tropical·Maria Sueli Parreira de ArrudaAna Paula Bordon
Nov 1, 1994·Mycopathologia·M S ArrudaM R Montenegro
Jan 1, 1987·Critical Reviews in Microbiology·E Segal
Jul 1, 1995·Revista Do Instituto De Medicina Tropical De São Paulo·M S de Arruda, M R Montenegro
Mar 14, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·M S de ArrudaF R Vilani-Moreno
Jan 1, 1970·Mycopathologia et mycologia applicata·H B LevineJ M Cobb

Related Concepts

Antigens
BCG Vaccine
Coccidioides immitis
Freund's Adjuvant
Delayed Hypersensitivity
Skin
Tuberculin Test
Vaccination

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