Delayed diagnosis of HIV infection and late initiation of antiretroviral therapy in the Swiss HIV Cohort Study

HIV Medicine
M WolbersSwiss HIV Cohort Study

Abstract

To investigate delayed HIV diagnosis and late initiation of antiretroviral therapy (ART) in the Swiss HIV Cohort Study. Two sub-populations were included: 1915 patients with HIV diagnosis from 1998 to 2007 and within 3 months of cohort registration (group A), and 1730 treatment-naïve patients with CD4>or=200 cells/microL before their second cohort visit (group B). In group A, predictors for low initial CD4 cell counts were examined with a median regression. In group B, we studied predictors for CD4<200 cells/microL without ART despite cohort follow-up. Median initial CD4 cell count in group A was 331 cells/microL; 31% and 10% were <200 and <50 cells/microL, respectively. Risk factors for low CD4 count were age and non-White race. Homosexual transmission, intravenous drug use and living alone were protective. In group B, 30% initiated ART with CD4>or=200 cells/microL; 18% and 2% dropped to CD4 <200 and <50 cells/microL without ART, respectively. Sub-Saharan origin was associated with lower probability of CD4 <200 cells/microL without ART during follow-up. Median CD4 count at ART initiation was 207 and 253 cells/microL in groups A and B, respectively. CD4<200 cells/microL and, particularly, CD4<50 cells/microL before starting ART...Continue Reading

References

Nov 16, 2001·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·UNKNOWN Panel on Clinical Practices for Treatment of HIV infection
Feb 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Daniel KleinUNKNOWN Consortium for HIV/AIDS Interregional Research
Jul 11, 2003·Lancet·A MocroftUNKNOWN EuroSIDA study group
Jun 29, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Enrico GirardiUNKNOWN ICoNA Behavioural Epidemiology Study Group
Aug 15, 2006·JAMA : the Journal of the American Medical Association·Scott M HammerUNKNOWN International AIDS Society-USA panel
Dec 29, 2006·AIDS Patient Care and STDs·Cyrille DelpierreUNKNOWN NADIS Group
May 26, 2007·International Journal of STD & AIDS·Cyrille DelpierreUNKNOWN VESPA Study Group
Jun 30, 2007·BMJ : British Medical Journal·Catherine Dodds, Peter Weatherburn
Jun 30, 2007·BMJ : British Medical Journal·M HamillH W Jaffe
Jun 30, 2007·BMJ : British Medical Journal·Cyrille DelpierreFrance Lert
Sep 28, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Enrico GirardiAntonella D'Arminio Monforte

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Citations

Nov 6, 2010·European Journal of Public Health·Julia Del AmoFrancisco Bolúmar
Dec 2, 2009·International Journal of Epidemiology·UNKNOWN Swiss HIV Cohort StudyPatrick Francioli
Jan 7, 2011·The Journal of Infectious Diseases·A ZoufalyUNKNOWN ClinSurv Study Group
Apr 3, 2009·AIDS·Fabienne MarcellinUNKNOWN EVAL Study Group
Sep 1, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ronaldo I MoreiraRichard D Moore
Feb 27, 2014·The Pan African Medical Journal·Khadija SaidKlaus Reither
Apr 14, 2012·BMC Infectious Diseases·Jörg SchüpbachUNKNOWN Swiss HIV Cohort Study
May 4, 2013·BMC Infectious Diseases·Karen ChampenoisYazdan Yazdanpanah
Jul 14, 2010·BMC Public Health·Jin-Hee LeeMee-Kyung Kee
Feb 5, 2013·Journal of Health Care for the Poor and Underserved·Maria LahuertaDenis Nash
Jul 11, 2008·PLoS Medicine·Olivia KeiserUNKNOWN Swiss HIV Cohort Study (SHCS) and the International Epidemiologic Databases to Evaluate AIDS in Southern Africa (IeDEA-SA)
Oct 14, 2010·PLoS Pathogens·Samuel AlizonUNKNOWN Swiss HIV Cohort Study
Jan 12, 2013·Journal of the International AIDS Society·Simeon MetallidisPavlos Nikolaidis
Mar 26, 2014·AIDS Patient Care and STDs·Mary Jo TrepkaSpencer Lieb
Nov 28, 2013·Clinical Interventions in Aging·Tiansheng Xie, Nanping Wu
Sep 22, 2012·Der Internist·M StöckleM Battegay
Jun 2, 2011·AIDS and Behavior·Olivia KeiserUNKNOWN Swiss HIV Cohort Study
Jan 6, 2012·AIDS and Behavior·Abraham MukoloKenneth A Wallston
Nov 10, 2011·Scandinavian Journal of Infectious Diseases·Marie HellebergNiels Obel
Sep 24, 2011·AIDS Research and Treatment·Kate BuchaczJohn T Brooks
Jan 25, 2011·The Journal of the Association of Nurses in AIDS Care : JANAC·Gisella Souza PereiraSheila Araújo Teles
Feb 28, 2016·The Journal of Infection·Paz Sobrino-VegasUNKNOWN Cohorte de la Red de Investigación en Sida, Spain
Nov 19, 2011·HIV Medicine·A ZoufalyUNKNOWN ClinSurv Study Group
Nov 21, 2015·Journal of the International AIDS Society·Anna HachfeldUNKNOWN Swiss HIV Cohort Study

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