Delayed diagnosis of Q fever endocarditis in a rheumatoid arthritis patient

IDCases
Shailee Y ShahSteven M Gordon

Abstract

Chronic Q fever caused by Coxiella burnetii is uncommon in the United States and is most often associated with infective endocarditis. We present a 52-year-old woman with a history of aortic valve replacement and rheumatoid arthritis treated with Etanercept with chronic Q fever manifesting as prosthetic valve infective endocarditis. Explanted valve tissue showed organisms confirmed to be C. burnetii by PCR (polymerase chain reaction) sequencing. She subsequently reported consumption of unpasteurized cow milk which was the likely source of C. burnetii. She continues to do well 6 months after valve replacement on oral doxycycline and hydroxychloroquine.

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Citations

Aug 21, 2016·International Journal of Food Microbiology·Alessia GalieroDomenico Cerri
Oct 2, 2019·Journal of Veterinary Research·Agnieszka JodełkoKrzysztof Niemczuk
Sep 23, 2016·Case Reports in Infectious Diseases·Julianna HirschGleb Slobodin
Jun 24, 2021·Case Reports in Rheumatology·A GuigaN Ghannouchi
Sep 28, 2021·Virulence·Halie K MillerGilbert J Kersh

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Methods Mentioned

BETA
biopsy
PCR

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