Delayed elevation of platelet activating factor in ischemic hippocampus

Brain Research
L C PettigrewR A Yokel

Abstract

We used in vivo microdialysis to define the chronological relationship between release of thromboxane and platelet activating factor (PAF) into the extracellular space of ischemic hippocampus. The thromboxane level peaked after 20 min of postischemic reperfusion, followed by a delayed PAF response 120 min later. We conclude that cerebral ischemia causes delayed elevation of PAF in the extracellular space, long after the immediate synthesis and release of thromboxane metabolites.

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Citations

Dec 1, 1996·Progress in Neurobiology·K M MaclennanC L Darlington
Apr 2, 2002·Neuroreport·Mary Ellen Hostettler, Sonia L Carlson
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Oct 3, 1999·Physiological Reviews·P Lipton

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