Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder

Neurology
C H SchenckM W Mahowald

Abstract

We report longitudinal data on a group of 29 male patients 50 years of age or older who were initially diagnosed as having idiopathic REM sleep behavior disorder (RBD) after extensive polysomnographic and neurologic evaluations. Thirty-eight percent (11/29) were eventually diagnosed as having a parkinsonian disorder (presumably Parkinson's disease) at a mean interval of 3.7 +/- 1.4 (SD) years after the diagnosis of RBD+, and at a mean interval of 12.7 +/- 7.3 years after the onset of RBD. To date, only 7% (2/29) of patients have developed any other neurologic disorder. At the time of RBD diagnosis, data from the RBD group with eventual Parkinson's disease (n = 11) and the current idiopathic RBD group (n = 16) were indistinguishable, with two exceptions: the RBD-Parkinson's disease group had a significantly elevated hourly index of periodic limb movements of non-REM sleep and an elevated REM sleep percentage. RBD was fully or substantially controlled with nightly clonazepam treatment in 89% (24/27) of patients in both groups. Thus, RBD can be the heralding manifestation of Parkinson's disease in a substantial subgroup of older male RBD patients. However, a number of presumed Parkinson's disease patients may eventually be diagnos...Continue Reading

Citations

Aug 2, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·B F BoeveJ E Parisi
Mar 29, 2007·Der Nervenarzt·N J Diederich
Feb 12, 2008·Acta Neuropathologica·Dennis W DicksonJ Eric Ahlskog
Jul 7, 2005·Journal of Neurology·Spiridon Papapetropoulos, D C Mash
Nov 30, 2006·Journal of Neurology·Werner Poewe
Jan 25, 2008·Journal of Neurology·Marie-Helene MarionOliver Foster
Sep 20, 2008·Journal of Neurology·K Ray Chaudhuri, Yogini Naidu
Sep 4, 2009·Journal of Neurology·Ariane Park, Mark Stacy
Nov 9, 2011·Journal of Neurology·Birgit FrauscherWerner Poewe
Aug 6, 2005·Journal of Neural Transmission·I GhorayebF Tison
Aug 15, 2009·Journal of Neural Transmission·Matthias LöhleHeinz Reichmann
Jul 1, 2011·Journal of Neural Transmission·Paulo Bugalho, Teresa Paiva
Jul 1, 2005·Current Neurology and Neuroscience Reports·K Ray ChaudhuriP Martinez-Martin
Jul 11, 2006·Current Neurology and Neuroscience Reports·Andrew Siderowf, Matthew B Stern
Mar 16, 2007·Current Neurology and Neuroscience Reports·Mark W MahowaldMichel A Cramer Bornemann
Feb 14, 2012·Current Neurology and Neuroscience Reports·Stuart J McCarterBradley F Boeve
Sep 17, 2002·Current Psychiatry Reports·Stephen Brooks, Clete A Kushida
Oct 3, 2001·Current Treatment Options in Neurology·Theresa A. ZesiewiczRobert A. Hauser
Feb 6, 2002·Current Treatment Options in Neurology·Matthias K. Lee, Christian Guilleminault
Apr 3, 2003·Current Treatment Options in Neurology·David B. Rye
Aug 14, 2012·Current Treatment Options in Neurology·Luigi Ferini-Strambi, Sara Marelli
Sep 12, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael J Howell
May 11, 2005·Parkinsonism & Related Disorders·Winona TseWilliam C Koller
Jun 7, 2005·Primary Care·Alon Y Avidan
Mar 23, 2004·Sleep Medicine·Stefania Brotini, Gian Luigi Gigli
Nov 1, 1996·Journal of the Neurological Sciences·J Kohyama
Mar 25, 1998·Journal of the Neurological Sciences·B El-Ad, A D Korczyn
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
Jun 4, 1999·Trends in Neurosciences·E PerryR Perry
Jan 29, 2002·Neurophysiologie clinique = Clinical neurophysiology·A AutretB de Toffol
Aug 18, 2004·Sleep Medicine Reviews·E SforzaC Petiau
Jul 2, 2008·Parkinsonism & Related Disorders·P K PalJ A Fleming
Nov 1, 2003·Sleep Medicine·Robert Daniel Vorona, J Catesby Ware
May 24, 2005·Lancet Neurology·Ramon MocellinE Bruce Tomlinson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.