Delayed exacerbation of acute myocardial ischemia/reperfusion-induced arrhythmia by tracheal instillation of diesel exhaust particles

Inhalation Toxicology
Syunji YokotaAtsunaka Kato

Abstract

For understanding the relationship between the increased incidence of sudden cardiac death and air pollution, we examined the effects of intratracheal instillation of diesel exhaust particles (DEP) on acute myocardial ischemia/reperfusion-induced arrhythmia in rats. The animals received 1 mg DEP 24-48 h before the ischemia/reperfusion (DEP-pretreated group, DEP-PRE), and were subjected to 3 successive brief ischemia/reperfusion (3 min ischemia followed by 5 min reperfusion) procedures. These were to make the animals tolerant to ischemia/reperfusion-related myocardial deterioration. Thereafter the animals were subjected to a 10-min ischemia followed by a 30-min reperfusion. In the experiments, an increased mortality was observed in the DEP-PRE group compared to the vehicle (0.05% Tween 80-PBS)-treated group. Forty-six percent of the animals in DEP-PRE died during the first 3-min reperfusion period. The animals of other groups were intratracheally instilled with DEP at the beginning of ischemia/reperfusion experiment, or were pretreated with polyethylene glycol-conjugated superoxide dismutase (1000 IU kg(-1), iv). In these animals, incidences of both arrhythmia and mortality were similar to those in the animals treated with the v...Continue Reading

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Citations

Dec 12, 2012·The Canadian Journal of Cardiology·Alex WatkinsKumaraswamy Nanthakumar
Nov 17, 2009·Toxicology Letters·Chien-Hua HuangWen-Jone Chen
Aug 22, 2006·Pharmacology & Therapeutics·Ni BaiIsmail Laher
Jun 15, 2015·Analytical and Bioanalytical Chemistry·M Ian GilmourMichael D Hays
Aug 23, 2008·Journal of the American College of Cardiology·Boris Z SimkhovichRobert A Kloner
Apr 14, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Jason N Peart, John P Headrick
Mar 13, 2009·Critical Reviews in Toxicology·Thomas W HesterbergPeter A Valberg

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