Delayed exercise-induced protection against arrhythmias in dogs--effect of celecoxib

European Journal of Pharmacology
Orsolya NagyAgnes Végh

Abstract

A 20-min period of treadmill exercise in dogs, sufficient to increase heart rate by 90-100 beats min(-1), markedly decreases the severity of the life-threatening ventricular arrhythmias that result when, following anaesthesia 24 h later, the left coronary artery is occluded. This protection was unaffected by the administration of the selective cyclooxygenase-2 inhibitor celecoxib (two times 3 mg kg(-1) given intravenously). These results show that prostacyclin, derived from cyclooxygenase-2, plays no role in this pronounced delayed cardioprotection.

Citations

Aug 23, 2011·Medicine and Science in Sports and Exercise·Lindsey E MillerJohn C Quindry
Mar 16, 2011·Cardiology Research and Practice·Saeid Golbidi, Ismail Laher
Sep 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ryan P TaylorJoseph W Starnes
Sep 7, 2007·Medicine and Science in Sports and Exercise·Joseph W Starnes, Ryan P Taylor
Jan 3, 2014·Physiology·Scott K PowersJohn C Quindry

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