Delayed exercise promotes remodeling in sub-rupture fatigue damaged tendons

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Rebecca BellN Andarawis-Puri

Abstract

Tendinopathy is a common musculoskeletal injury whose treatment is limited by ineffective therapeutic interventions. Previously we have shown that tendons ineffectively repair early sub-rupture fatigue damage. In contrast, physiological exercise has been shown to promote remodeling of healthy tendons but its utility as a therapeutic to promote repair of fatigue damaged tendons remains unknown. Therefore, the objective of this study was to assess the utility of exercise initiated 1 and 14 days after onset of fatigue damage to promote structural repair in fatigue damaged tendons. We hypothesized that exercise initiated 14 days after fatigue loading would promote remodeling as indicated by a decrease in area of collagen matrix damage, increased procollagen I and decorin, while decreasing proteins indicative of tendinopathy. Rats engaged in 6-week exercise for 30 min/day or 60 min/day starting 1 or 14 days after fatigue loading. Initiating exercise 1-day after onset of fatigue injury led to exacerbation of matrix damage, particularly at the tendon insertion. Initiating exercise 14 days after onset of fatigue injury led to remodeling of damaged regions in the midsubstance and collagen synthesis at the insertion. Physiological exerci...Continue Reading

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Citations

Oct 22, 2016·Annals of the New York Academy of Sciences·J J Paredes, Nelly Andarawis-Puri
Sep 4, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nelly Andarawis-Puri, Evan L Flatow
May 23, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Juan ParedesNelly Andarawis-Puri
May 26, 2021·Connective Tissue Research·Monideepa ChatterjeeNelly Andarawis-Puri

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