Delayed Gastric Emptying in Functional Dyspepsia

Current Treatment Options in Gastroenterology
Vincenzo StanghelliniRoberto Corinaldesi

Abstract

Functional dyspepsia is a complex syndrome with a poorly defined pathophysiology, resulting in uncertainties in its therapeutic approach. Abnormalities in gastrointestinal motility and sensitivity alone or combined seem to play a role in a substantial subgroup of patients. Drugs capable of prokinetic effects, such as antidopaminergics (eg, metoclopramide, domperidone, levosulpiride) and serotonin 5-HT4 receptor agonists (eg, tegaserod) can be potentially used in the treatment of dyspeptic patients. Furthermore, 5-HT4 receptor agonists do not appear to increase the gastric fundus tone which may also contribute to improved symptoms in subsets of patients. Alosetron, a 5-HT3 receptor antagonist, has been investigated mainly in irritable bowel syndrome, and the few studies performed in functional dyspepsia have provided conflicting results. Erythromycin and related derivatives, the motilides, represent another class of prokinetic compounds able to accelerate gastric emptying and potentially indicated in functional dyspepsia. The stimulatory effect on fundic tone and the occurrence of tachyphilaxis hamper the efficacy of these drugs in the long-term treatment. kappa-opioid receptor agonists might be useful for functional digestive s...Continue Reading

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Citations

Dec 13, 2006·Journal of Gastroenterology·Yohei MizutaShigeru Kohno
Mar 25, 2008·Therapeutics and Clinical Risk Management·R LozanoH Burgos Quirós
Jun 7, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-L MaoZ-G Wang
Feb 22, 2017·World Journal of Gastrointestinal Pharmacology and Therapeutics·Shahab AbidAamir Abbas
Jun 2, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S ZhangJ D Z Chen
Nov 23, 2013·Biomolecules & Therapeutics·Yong Sam Kwon, Miwon Son
Apr 18, 2017·Experimental and Therapeutic Medicine·Wenping PanYan Lu
May 24, 2006·World Journal of Gastroenterology : WJG·Klaus Mönkemüller, Peter Malfertheiner
Jan 30, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Michael P JonesGerald Holtmann

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