Delayed growth, motor function and learning in preterm pigs during early postnatal life

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Anders Daniel AndersenThomas Thymann

Abstract

Preterm birth interrupts normal fetal growth with consequences for postnatal growth and organ development. In preterm infants, many physiological deficits adapt and disappear with advancing postnatal age but some may persist into childhood. We hypothesized that preterm birth would induce impaired organ growth and function during the first postnatal week in pigs while motor abilities and behavioral characteristics would show more persistent developmental delay. Caesarean-delivered preterm (n=112, 90% gestation) or term (n=56, 100% gestation) piglets were reared under identical conditions and sacrificed for blood and organ collections on postnatal days 0, 5 or 26. Body weight gain remained lower in preterm vs. term pigs up to day 26 (25.5±1.5 vs. 31.0±0.5 g/kg/d, P<0.01) when relative weights were higher for brain and kidneys, and reduced for liver and spleen. Neonatal preterm pigs had reduced values for blood pH, pO2, glucose, lactate, hematocrit and cortisol, but at day 26 most values were normalized, although plasma serotonin and insulin-like growth factor (IGF) 1 levels remained reduced. Preterm pigs showed delayed neonatal arousal and impaired physical activity, coordination, exploration and learning, relative to term pigs (...Continue Reading

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Citations

Nov 11, 2016·Scientific Reports·Duc Ninh NguyenPer T Sangild
Jul 29, 2017·Journal of Pediatric Gastroenterology and Nutrition·Yanqi LiPer T Sangild
Jan 5, 2019·The Journal of Nutrition·Anders D AndersenThomas Thymann
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Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuqiang RenDuc Ninh Nguyen
Jan 12, 2019·Journal of Pediatric Gastroenterology and Nutrition·Shamrulazhar Shamzir KamalDennis Sandris Nielsen
Jan 29, 2020·Journal of Pediatric Gastroenterology and Nutrition·Victoria SmithDouglas Burrin
Jun 19, 2019·Nutrients·Karina Obelitz-RyomThomas Thymann
Sep 11, 2019·American Journal of Physiology. Endocrinology and Metabolism·Jane K NaberhuisTeresa A Davis
Oct 17, 2018·Nutrients·Karina Obelitz-RyomStine Brandt Bering
Feb 19, 2020·The Journal of Nutrition·Agnethe May AhnfeldtPer Torp Sangild
Aug 14, 2019·Frontiers in Physiology·Lisa M HortensiusCaroline G M de Theije
Jun 11, 2018·Journal of Neuroinflammation·Jing SunStanislava Pankratova
Jan 12, 2021·American Journal of Physiology. Endocrinology and Metabolism·Marko RudarTeresa A Davis
Feb 3, 2021·Nutrients·Kristine Bach Korsholm KnudsenThomas Thymann
Feb 23, 2021·Frontiers in Pediatrics·Kristine HolgersenPer Torp Sangild
Jul 13, 2021·Frontiers in Nutrition·Ester Arévalo SuredaThomas Thymann
Aug 28, 2021·Nutrients·Karoline Aasmul-OlsenStine Brandt Bering
Aug 28, 2021·Nutrients·Per Torp SangildDouglas G Burrin
May 30, 2019·Developmental Neuroscience·Charlotte Holme NielsenPer Torp Sangild

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