Delayed hypersensitivity and systemic arthralgia following transurethral collagen injection for stress urinary incontinence

The Journal of Urology
L Stothers, S L Goldenberg

Abstract

During a prospective cohort study to determine the effectiveness of and adverse effects associated with transurethral collagen injection for treatment of stress urinary incontinence in women, we observed 3 cases of delayed allergic reaction at the skin test site associated with arthralgia. A total of 337 women with at least a 1-year history, physical findings and urodynamic abnormalities consistent with stress urinary incontinence, who required pads or protective clothing and who had no or only grade 1 cystocele were enrolled in this prospective cohort study. Adverse effects were documented by a third party at each followup. Delayed reaction at the skin test site occurred in 3 patients (0.9%), and was associated with arthralgias in 2. The incidence and systemic nature of this type of reaction suggest that gluteraldehyde cross-linked collagen injection is not as innocuous as previously believed. Patients should be counseled regarding the unknown long-term outcome of this complication. Before treatment clinicians should consider double skin testing.

References

Mar 1, 1989·The Journal of Dermatologic Surgery and Oncology·M L Elson
Jan 1, 1985·Aesthetic Plastic Surgery·L S CoopermanB B Pharriss
Apr 1, 1987·Plastic and Reconstructive Surgery·F DeLustroL Ellingsworth
Apr 1, 1994·Urology·E J McGuire, R A Appell
Oct 1, 1996·The Journal of Urology·S HerschornS B Radomski

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Citations

Jul 21, 2010·International Urogynecology Journal·Ha Na LeeKyu-Sung Lee
Feb 23, 2011·International Urogynecology Journal·Disha KumarRoger R Dmochowski
Oct 8, 1999·Urology·R D CespedesE J McGuire
Dec 7, 2006·Nature Clinical Practice. Urology·Craig V Comiter
Oct 20, 1999·Current Opinion in Obstetrics & Gynecology·K Yasuda, T Yamanishi
Aug 28, 2004·Journal of Voice : Official Journal of the Voice Foundation·Timothy D Anderson, Robert T Sataloff
Aug 25, 2005·European Urology·Christopher R ChappleSimon Hill
Mar 22, 2014·Korean journal of urology·Sin Woo LeeKyu-Sung Lee
Aug 31, 2002·Scandinavian Journal of Urology and Nephrology·R PeekerM Fall
Sep 21, 2004·International Urogynecology Journal and Pelvic Floor Dysfunction·George LazarouMagdy S Mikhail
Jul 25, 2006·Expert Opinion on Pharmacotherapy·Petros Perimenis, Konstantinos Giannitsas
Jul 20, 2019·Neurourology and Urodynamics·B ToiaT Greenwell
Jun 20, 2000·Current Opinion in Urology·G M Ghoniem
Aug 25, 1999·Current Opinion in Urology·K C Kobashi, G E Leach
Nov 26, 1999·BJU International·E GortonD R Bland
Jan 17, 2002·The Journal of Urology·David A Ginsberg, Stuart D Boyd

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