Delayed hypersensitivity responses in children after local cutaneous anesthesia

Acta paediatrica Scandinavica
B BjörksténO Groth

Abstract

The effect of cutaneous analgesia on delayed type hypersensitivity (DTH) reactions as challenged by injections in the skin was assessed by comparing a lidocaine/prilocaine mixture with placebo. Application of 5 g of the mixture 90 min before testing significantly (p less than 0.001) reduced pain but did not influence the DH-reactions as read after 48 hours. Based on these findings, DTH to several antigens were measured in 116 school children, aged 7-15 years. All the children were positive to either tetanus antigen, 7.5 Lf/ml (98% at 48 hours) or mumps test antigen (82%), while positivity to tuberculin 2 TU/ml and candida 1000 PNU/ml were only 11 and 62% respectively. Therefore, DTH tests in an adequately immunized population of children can be limited to two antigens. Application of cutaneous analgesia is recommended as a routine procedure in DTH testing in young children.

References

May 1, 1979·The Journal of Trauma·L D MacLean
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Jun 1, 1982·The Journal of Allergy and Clinical Immunology·D R Ownby
Mar 1, 1983·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·T SymrengH Zetterqvist

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Citations

Feb 6, 2010·The Pediatric Infectious Disease Journal·Nicole BeydonCorinne Alberti

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