PMID: 9181258May 1, 1997Paper

Delayed increase in blood pressure induced by spontaneously hypertensive rat plasma after high sodium intake

Blood Pressure
I TikkanenH Karppanen

Abstract

Plasma from spontaneously hypertensive rats (SHR) and from patients with essential hypertension has been suggested to contain a substance with a delayed pressor effect, parathyroid hypertensive factor (PHF), associated with salt-sensitive forms of hypertension. In order to study whether high sodium intake would increase plasma levels of PHF-like activity, determined by bioassay, SHR received either a high-sodium (2.6% Na in the chow) or a normal-sodium (0.3% Na) diet for 6 weeks. Intravenous injection of plasma from SHR on a high-sodium diet (6 ml/kg) to urethane-anaesthetized Wistar rats induced a delayed increase in mean arterial blood pressure 70-80 min after bolus injection. No delayed pressor effects could be demonstrated by plasma from SHR or Wistar rats on a normal-sodium diet. It is concluded that a factor with a delayed blood pressure-increasing effect appears to be present in plasma from SHR on a high-sodium diet but not in plasma from normotensive Wistar rats or SHR on a normal-sodium diet. Further studies to characterize this factor and its possible relation to salt-induced hypertension are warranted.

References

Jun 1, 1992·Hypertension·E M MervaalaH Karppanen
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C G BenishinP K Pang
May 1, 1994·Blood Pressure·P K PangR Z Lewanczuk
Sep 1, 1993·American Journal of Hypertension·R Z Lewanczuk, P K Pang
Mar 1, 1996·Hypertension·M H Weinberger

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Citations

Nov 10, 1998·Clinical and Experimental Pharmacology & Physiology·G J MangosJ A Whitworth

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