Delayed intravascular catabolism of chylomicron-like emulsions is an independent predictor of coronary artery disease

Atherosclerosis
A C SpósitoRaul C Maranhão

Abstract

The atherogenic role of a delayed intravascular catabolism of chylomicrons has been suggested by univariate analysis of case-control studies. However, it is not established whether this association is caused by a direct atherogenic effect of these lipoproteins or results from the presence of concurrent and metabolically-related coronary artery disease (CAD) risk factors. In this study, the plasma kinetics of a chylomicron-like emulsion doubly labeled with 14C-cholesteryl oleate (CE) and 3H-triolein (TG) was determined in 93 subjects with or without angiographically-defined CAD. As compared with controls and even after adjustment for body mass index (BMI), LDL- and HDL-cholesterol, and the presence of traditional risk factors, CAD patients had 45% smaller fractional clearance rate (FCR) of TG, 41% smaller FCR-CE and 19% smaller dilapidation index (DI; P < 0.05). Among CAD patients, those with highest angiographic score had 66% smaller FCR-TG (P = 0.007), 50% smaller FCR-CE (P = 0.01) and 27% smaller DI (P = 0.004). In a multivariate logistic regression analysis, FCR-CE (P < 0.0001) and DI (P = 0.001) were the only independent predictors for the presence of CAD. In conclusion, we presently show that the rate of lipolysis and remo...Continue Reading

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Citations

Feb 7, 2013·Journal of Lipid Research·Qiaoling YaoVsevolod Y Polotsky
Sep 23, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J C VinagreR C Maranhão
Sep 4, 2012·Steroids·Aleksandra T MorikawaCarmen G C Vinagre
Jan 19, 2013·Journal of Liposome Research·Aranzazu Antelo, Javier S Perona
May 21, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Cecilia M DevlinIra Tabas
Nov 27, 2018·Sleep·David Barros, Francisco García-Río
Feb 6, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Raul C MaranhãoFatima R Freitas

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