Delayed logistic indirect response models: realization of oscillating behavior

Journal of Pharmacokinetics and Pharmacodynamics
Gilbert Koch, Johannes Schropp

Abstract

Indirect response (IDR) models are probably the most frequently applied tools relating the effect of a signal to a baseline response. A response modeled by such a classical IDR model will always return monotonously to its baseline after drug administration. We extend IDR models with a delay process, i.e. a retarded response state, that leads to oscillating response behavior. First, IDR models with a first-order production and second-order loss term based on the famous logistic equation are constructed. Second, a delay process similar to the delayed logistic equation is included. Relations of the classical IDR model with our extended IDR model concerning response and model parameters are revealed. Simulations of typical response profiles are presented and data fitting of a model for leptin and cholesterol dynamics after administration of methylprednisolone is performed. The influence of the delay parameter on the other model parameters is discussed.

References

Aug 1, 1993·Journal of Pharmacokinetics and Biopharmaceutics·N L DaynekaW J Jusko
Apr 3, 1999·Journal of Pharmaceutical Sciences·A SharmaW J Jusko
Oct 26, 1999·Journal of Pharmacokinetics and Biopharmaceutics·A ChakrabortyW J Jusko
Aug 19, 2000·Journal of Pharmacokinetics and Biopharmaceutics·W KrzyzanskiW J Jusko
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K P ZuideveldM Danhof
Aug 17, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Wojciech KrzyzanskiWing K Cheung
Dec 27, 2005·Journal of Theoretical Biology·Julien ArinoGail S K Wolkowicz
Aug 11, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Johan Gabrielsson, Lambertus A Peletier
Oct 13, 1948·Annals of the New York Academy of Sciences·G E HUTCHINSON
Sep 4, 2009·Clinical Pharmacokinetics·Juan José Pérez-RuixoHugh M Davis
May 11, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Davide Verotta
Mar 15, 2011·The Journal of Pharmacology and Experimental Therapeutics·Siddharth SukumaranRichard R Almon
Jan 4, 2012·Journal of Pharmacokinetics and Pharmacodynamics·Wojciech Krzyzanski, Juan Jose Perez Ruixo
Aug 22, 2014·Journal of Pharmacokinetics and Pharmacodynamics·Gilbert KochJohannes Schropp
Jul 11, 2016·Journal of Pharmacokinetics and Pharmacodynamics·Yaping Zhang, David Z D'Argenio

❮ Previous
Next ❯

Citations

Jan 30, 2019·Journal of Pharmacokinetics and Pharmacodynamics·Vivaswath S AyyarWilliam J Jusko
Feb 2, 2021·Journal of Pharmacokinetics and Pharmacodynamics·Gilbert KochAlexandre N Datta
Feb 10, 2021·Journal of Pharmacokinetics and Pharmacodynamics·Begum AlaybeyogluAndrew M Stein
Apr 3, 2021·Journal of Pharmacokinetics and Pharmacodynamics·Vivaswath S Ayyar, Siddharth Sukumaran

❮ Previous
Next ❯

Software Mentioned

Matlab
Monolix Suite

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.