PMID: 7540191Mar 1, 1995Paper

Delayed myelination in infants and young children: radiographic and clinical correlates

Journal of Child Neurology
L A SquiresM R Natowicz

Abstract

Magnetic resonance imaging (MRI) is the best method for assessing myelination in infants and young children. Although delayed myelination is a common neuroradiologic diagnosis, there are few or no data regarding the reliability of this diagnosis or radiographic and clinical findings in cohorts of such patients. We evaluated the cranial MRI scans of 109 patients from age 0 to 36 months, without knowledge of any patient's age or previous clinical or radiologic diagnosis. For each cranial MRI, seven neuroradiologic landmarks were evaluated and established criteria used to assess the state of myelination. We found that in 12 of 109 patients, delayed myelination was misdiagnosed, whereas the diagnosis of delayed myelination was missed in four other patients. Lack of familiarity with the myelination milestones of infancy was the most common reason for a misdiagnosis of delayed myelination. Failure to recognize delayed myelination was due to a failure to appreciate the forceps minor as a landmark. Overall, the diagnosis of delayed myelination was inaccurately applied or missed in 15% of the patients in this series. Of the 14 patients identified as having delayed myelination, 10 had other central nervous system structural abnormalities...Continue Reading

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Citations

Feb 22, 2003·European Journal of Radiology·Daniela Prayer, Lucas Prayer
Aug 16, 2003·Radiology·Christopher G FilippiAziz M Uluğ
Jul 20, 2011·Journal of Pediatric Ophthalmology and Strabismus·Yasser H Al-FakyAbdul Rahman Al-Mosallam
Oct 14, 2008·International Journal of Pediatric Otorhinolaryngology·Peijen SuKazuo Mima
Oct 6, 1997·Journal of Child Neurology·J B BodensteinerM K Bowen
Sep 27, 2008·Journal of Oral Science·Kaan GündüzPinar Sümer
Jun 25, 2009·Journal of Oral Science·Flávia S F TomazinhoEdson A de Campos

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