Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia

Brain Research
T YamamotoK Kogure

Abstract

The salicylate-trapping method was used to detect hydroxyl radicals by measurement of stable adduct dihydroxybenzoic acid (DHBA). Ten minutes of forebrain ischemia followed by reperfusion induced the increase in DHBA in rat hippocampal perfusates. Postischemic treatment with a free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), significantly reduced the increase in DHBA and suppressed delayed neuronal death in the hippocampal CA1 region.

References

Nov 24, 1999·Journal of Neuroscience Research·A M RaoR J Dempsey
May 19, 2010·Journal of Anesthesia·Chihiro ShinguTakayuki Noguchi
Dec 16, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M Badruzzaman KhanFakhrul Islam
Jan 25, 2011·Inflammation·Masaaki YoshimotoKiyonori Yamaoka
Nov 19, 2003·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Yasunori ChoRyohei Yozu
Sep 17, 2005·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Kenichi HashizumeRyohei Yozu
Dec 11, 2007·Molecular Neurobiology·Venkata Prasuja NakkaRam Raghubir
Mar 23, 2004·European Journal of Pharmacology·Tsuyoshi TakemotoHiroshi Yamashita
Dec 19, 2003·Free Radical Biology & Medicine·Mayumi YamatoHideo Utsumi
Feb 26, 2003·European Journal of Pharmacology·Osamu HoriikeHiroshi Yamashita
Dec 7, 2002·Life Sciences·Kyuya Kogure
Jul 25, 2009·Antioxidants & Redox Signaling·Rao Muralikrishna Adibhatla, James Franklin Hatcher
Oct 16, 1999·Pharmacology & Toxicology·T KitaT Nakashima
Feb 6, 2004·Chemical & Pharmaceutical Bulletin·Shinji AbeToshiaki Tamaki
Jun 14, 2002·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Masahiko Tanaka
Apr 6, 2006·Internal Medicine·Yuichiro InatomiMakoto Uchino
Jul 26, 2005·Neurologia Medico-chirurgica·Masahiro MishinaYasuo Katayama
Jul 28, 2012·International Journal of Molecular Sciences·Kiyoshi KikuchiEiichiro Tanaka
Jul 25, 2013·International Journal of Molecular Sciences·Kiyoshi KikuchiEiichiro Tanaka
Sep 26, 2013·Oxidative Medicine and Cellular Longevity·Kenji DohiTohru Aruga
Mar 27, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mustafa KaraOzgul Tap
Oct 5, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Syoichiro KonoKoji Abe

Citations

May 1, 1979·Stroke; a Journal of Cerebral Circulation·W A Pulsinelli, J B Brierley
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·C BromontJ Bralet
Jul 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T WatanabeS Murota
May 23, 1994·Neuroscience Letters·T AraiS Kojima

Related Concepts

Ischemia
Reperfusion Injury
2-pyrocatechuic acid, sodium salt
Iron Chelating Agents
Phenylmethylpyrazolone
Hydroxyl Radical
Neurons
Free Radicals
MCI 186
Radicals (chemistry)

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