Delayed neurotrophic treatment preserves nerve survival and electrophysiological responsiveness in neomycin-deafened guinea pigs

Journal of Neuroscience Research
Takahiko YamagataGöran Bredberg

Abstract

Benefits of cochlear prostheses for the deaf are dependent on survival and excitability of the auditory nerve. Degeneration of deafferented auditory nerve fibers is prevented and excitability maintained by immediate replacement therapy with exogenous neurotrophic factors, in vivo. It is important to know whether such interventions are effective after a delay following deafness, typical for the human situation. This study evaluated the efficacy of brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor axokine-1 analogue (CNTF Ax1) application, 2 or 6 weeks postdeafening, in preventing further degeneration and a decrease in excitability. Guinea pigs were deafened and implanted with intracochlear stimulating electrodes, a scala tympani cannula-osmotic pump system, and auditory brainstem response (ABR) recording electrodes. Subjects received BDNF + CNTF Ax1 or artificial perilymph (AP) treatment for 27 days, beginning at 2 or 6 weeks following deafening. Electrical (E) ABR thresholds increased following deafening. After 1 week, in the 2-weeks-delayed neurotrophic factor treatment group, EABR thresholds decreased relative to AP controls, which were statistically significant at 2 weeks. In the 6-week delay group, a ...Continue Reading

References

Aug 1, 1978·The Laryngoscope·M H Stroud
Jul 1, 1991·The Annals of Otology, Rhinology, and Laryngology·P R KilenyS P Schmaltz
Dec 1, 1989·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R W JyungS C Cannon
Jun 1, 1989·The Annals of Otology, Rhinology, and Laryngology·J B NadolR J Glynn
Sep 1, 1989·Neurobiology of Aging·E M JohnsonD P Martin
Jan 1, 1971·Archiv für klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde·H Spoendlin
Dec 1, 1993·The Annals of Otology, Rhinology, and Laryngology·B J GantzR S Tyler
Nov 1, 1993·Hearing Research·J N BrownA L Nuttall
Mar 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·V M VergeP M Richardson
Jul 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J M MillerR A Altschuler
Oct 23, 1997·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J B Nadol
Nov 19, 1997·Journal of Neuroscience Research·H Jiang, G Guroff
Nov 30, 1999·Nature·K W KafitzA Konnerth
Feb 17, 2000·Hearing Research·D M Prieskorn, J M Miller
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M G Vander HeidenC B Thompson
Jun 8, 2000·Annals of the New York Academy of Sciences·R Pujol, J L Puel
Jun 8, 2000·Annals of the New York Academy of Sciences·R A AltschulerJ M Miller
Mar 30, 2001·Journal of Neurocytology·H C Dodson, A Mohuiddin
Sep 18, 2001·The Annals of Otology, Rhinology, and Laryngology·J B NadolJ K Shallop
Jan 22, 2002·The Laryngoscope·R HinojosaD R Schramm
Jan 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Takayuki ShinoharaJosef M Miller
May 7, 2002·The Annals of Otology, Rhinology, and Laryngology·Kate GfellerJohn Knutson

❮ Previous
Next ❯

Citations

Nov 17, 2011·Journal of the Association for Research in Otolaryngology : JARO·David J SlyStephen J O'Leary
Jul 6, 2010·Journal of Neurotrauma·Anette FranssonMats Ulfendahl
Jul 24, 2012·Therapeutic Delivery·Takayuki Nakagawa, Juichi Ito
Apr 15, 2009·Journal of the Association for Research in Otolaryngology : JARO·Martijn J H AgterbergSjaak F L Klis
Sep 27, 2008·Expert Opinion on Drug Delivery·Rachael T RichardsonStephen J O'Leary
Apr 3, 2012·Hearing Research·Dyan RamekersSjaak F L Klis
May 3, 2011·Hearing Research·Bryony A NayagamDavid K Ryugo
May 12, 2009·Journal of Neuroscience Methods·Jennifer A ChikarYehoash Raphael
Dec 5, 2006·Hearing Research·Colleen G Le PrellJosef M Miller
Nov 23, 2006·Neurobiology of Disease·Jun MaruyamaJosef M Miller
Nov 3, 2005·The European Journal of Neuroscience·Lisa N Gillespie, Robert K Shepherd
Apr 1, 2011·The Journal of Comparative Neurology·Patricia A LeakeOlga Stakhovskaya
Aug 3, 2010·The European Journal of Neuroscience·Futoshi WatanabeAnders Fridberger
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Cameron L BudenzYehoash Raphael
Jun 7, 2007·IEEE Transactions on Bio-medical Engineering·Lisa N PettingillRobert K Shepherd
Jan 24, 2015·Journal of Neuroscience Research·Daisuke YamashitaTatsuo Matsunaga
Aug 11, 2015·Frontiers in Aging Neuroscience·Anette FranssonMats Ulfendahl
Jul 9, 2008·Acta Oto-laryngologica·Bing-Nan SongDe-Min Han
Dec 8, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lisa N GillespieRobert K Shepherd
Jun 15, 2017·Tissue Engineering. Part a·Michael StolleAthanasia Warnecke
Jun 4, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Kirsten WisselAndrea Hoffmann
Nov 29, 2012·Journal of Neural Engineering·Andrew K Wise, Lisa N Gillespie
Sep 19, 2019·Advanced Healthcare Materials·Jongmoon JangJeong Hun Jang
Jun 7, 2020·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Brian W BlakleyAbdulrahman Alenezi
Mar 2, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Laurien WaaijerWilko Grolman
Jul 17, 2015·Advanced Healthcare Materials·Sahar RahmaniJoerg Lahann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.