Delayed olfactory ensheathing cell transplants reduce nociception after dorsal root injury

Experimental Neurology
Ann WuPhil M E Waite

Abstract

Injury to cervical dorsal roots mimics the deafferentation component of brachial plexus injury in humans, with intractable neuropathic pain in the deafferented limb being a common consequence. Such lesions are generally not amenable to surgical repair. The use of olfactory ensheathing cells (OECs) for dorsal root repair, via acute transplantation, has been successful in several studies. From a clinical point of view, delayed transplantation of OECs would provide a more realistic timeframe for repair. In this study we investigated the effect of delayed OEC transplantation on functional recovery of skilled forepaw movements and amelioration of neuropathic pain, using a C7 and C8 dorsal root injury rat model previously established in our lab. We found that OEC transplantation to the dorsal horn 1 week after root injury effectively attenuated neuropathic disturbances associated with dorsal root injury, including spontaneous pain behavior, tactile allodynia and thermal hyperalgesia. The sensory controls of complex, goal-oriented skilled reaching and ladder walking, however, were not improved by delayed OEC transplantation. We did not detect any significant influence of transplanted OECs on injury-induced central reorganisation and a...Continue Reading

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Citations

Dec 4, 2012·International Journal of Molecular Sciences·Christine Radtke, Jeffery D Kocsis
May 21, 2014·Experimental Neurology·Kasper C D Roet, Joost Verhaagen
Oct 16, 2010·Experimental Neurology·Almudena Ramón-Cueto, Cintia Muñoz-Quiles
Sep 3, 2013·Cell Transplantation·Lin ChenPaul R Sanberg

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