Delayed-Onset Nodules to Differentially Crosslinked Hyaluronic Acids: Comparative Incidence and Risk Assessment

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Mona SadeghpourMichael S Kaminer

Abstract

Robust and long-term data on true incidence of delayed-onset nodules and immune tolerance of hyaluronic acid (HA) fillers are lacking. To characterize the incidence of delayed nodules in Vycross (VYC) HA fillers compared with previously reported FDA and non-FDA data of all HA fillers. The incidence of delayed nodules in all patients who had received VYC fillers in a 12-month period was assessed through a retrospective chart review. Nodule incidence for currently approved nonanimal-stabilized hyaluronic acid (NASHA) fillers was assessed using the FDA Summary of Safety and Effectiveness Data. Overall, 1,029 patients received 1,250 VYC filler treatments. Five patients developed delayed nodules to VOB, with an incidence of 1.0% per patient and 0.8% per syringe. No nodules were observed in patients who received VLR or VOL. All nodules were treated successfully using a combination of intralesional triamcinolone and hyaluronidase. Compared with other currently approved NASHA fillers, VOB is associated with a higher incidence of nodule formation. The introduction of VYC HAs has introduced a new variable that may be changing the immune tolerance of these substances, resulting in a higher incidence of delayed nodules than previously expe...Continue Reading

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Citations

Jul 6, 2020·Journal of Cosmetic Dermatology·Dario BertossiMauricio de Maio
May 16, 2020·Journal of Cosmetic Dermatology·Kerry HeitmillerNazanin Saedi
Jun 18, 2020·Clinical, Cosmetic and Investigational Dermatology·Ofir ArtziDana Shalmon
Mar 19, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Stephen Mandy
May 23, 2020·Plastic and Reconstructive Surgery. Global Open·Wolfgang G Philipp-DormstonRami K Batniji
Dec 22, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kenneth BeerAndrew Schumacher
Feb 6, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Derek H JonesMurad Alam
Aug 23, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Angela BurleighDiana Diao
Jul 24, 2021·Clinical, Cosmetic and Investigational Dermatology·Agnieszka Owczarczyk-SaczonekWaldemar Placek
Aug 20, 2021·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Sukran Sarigul Guduk
Oct 6, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Danny Mansour, Vincent Richer
Dec 23, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Joel L CohenBill Andriopoulos

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