PMID: 8583615Mar 1, 1996Paper

Delayed orchiectomy after chemotherapy for metastatic nonseminomatous germ cell tumors

The Journal of Urology
I LeibovitchJ P Donohue

Abstract

We reviewed current experience at our university with delayed orchiectomy after chemotherapy in patients with metastatic nonseminomatous germ cell tumors. We retrospectively analyzed the records of 160 patients with metastatic germ cell cancer who were given systemic chemotherapy, and subsequently underwent orchiectomy and retroperitoneal lymph node dissection. Analysis of 160 testicular specimens revealed necrosis or scar in 70 (43.7%), pure teratoma in 50 (31.2%) and persistent germ cell cancer in 40 (25%). Corresponding incidences of histopathological findings in the post-chemotherapy retroperitoneal lymph node dissection specimens were significantly different, correlating with less than half of the cases (chi-square, p = 0.002). Our study confirms the need for delayed orchiectomy after systemic chemotherapy even when there seems to be a partial or complete clinical response at other sites.

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Citations

Jun 21, 2008·Der Urologe. Ausg. A·L Weissbach, C Schaefer
Nov 7, 2016·Journal of Medical Case Reports·Angela MweempwaMichael Dray
Jan 22, 2005·Critical Reviews in Oncology/hematology·Stefania GoriMaurizio Marangolo
Sep 3, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J BartW T A van der Graaf
Jun 1, 1997·Annals of Surgical Oncology·J P van BastenH Schraffordt Koops
Nov 10, 2004·Urology·Steven R Mindrup, Badrinath R Konety
Aug 21, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J SchmollUNKNOWN European Germ Cell Cancer Consensus Group

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