Abstract
Obesity, especially visceral obesity, has been known to affect lipoprotein metabolism, but it is not clear whether obesity in young, apparently healthy men is associated with postprandial triglyceride-rich lipoprotein (TRL) metabolism. Ten young normolipidemic, normoglycemic obese men (20.6 ± 0.5 y, BMI 27.5 ± 1.0 kg/m(2)) and 11 lean healthy men (22.1 ± 0.4 y, 21.2 ± 0.4 kg/m(2)) ingested OFTT cream (1g/kg body weight). Fasting and postprandial blood samples were obtained for up to 6h, and serum lipids and lipoproteins were analyzed. The obese men with a fasting triglyceride (TG) in the normal range and not different from the fasting value of lean controls had a prolonged postprandial response, indicated by a significantly greater incremental areas under the curve in serum TG, TRL-TG, and remnant-like particle-cholesterol (RLP-C) compared with controls. Plasma glucose levels did not change during the test. Differences in serum insulin levels and homeostasis model assessment-insulin resistance (HOMA-IR) were not statistically significant between the two groups; however, trends toward higher levels were shown in obese young men. The obese young men showed significantly delayed TRL metabolism compared to the lean young men after ...Continue Reading
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