Delayed postprandial metabolism of triglyceride-rich lipoproteins in obese young men compared to lean young men

Clinica Chimica Acta; International Journal of Clinical Chemistry
Yuka Nabeno-KaeriyamaMichitaka Naito

Abstract

Obesity, especially visceral obesity, has been known to affect lipoprotein metabolism, but it is not clear whether obesity in young, apparently healthy men is associated with postprandial triglyceride-rich lipoprotein (TRL) metabolism. Ten young normolipidemic, normoglycemic obese men (20.6 ± 0.5 y, BMI 27.5 ± 1.0 kg/m(2)) and 11 lean healthy men (22.1 ± 0.4 y, 21.2 ± 0.4 kg/m(2)) ingested OFTT cream (1g/kg body weight). Fasting and postprandial blood samples were obtained for up to 6h, and serum lipids and lipoproteins were analyzed. The obese men with a fasting triglyceride (TG) in the normal range and not different from the fasting value of lean controls had a prolonged postprandial response, indicated by a significantly greater incremental areas under the curve in serum TG, TRL-TG, and remnant-like particle-cholesterol (RLP-C) compared with controls. Plasma glucose levels did not change during the test. Differences in serum insulin levels and homeostasis model assessment-insulin resistance (HOMA-IR) were not statistically significant between the two groups; however, trends toward higher levels were shown in obese young men. The obese young men showed significantly delayed TRL metabolism compared to the lean young men after ...Continue Reading

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Citations

Feb 15, 2012·Advances in Nutrition·Michael R FlockPenny M Kris-Etherton
Nov 17, 2012·Journal of Atherosclerosis and Thrombosis·Sayuki HashimotoMichitaka Naito
Apr 24, 2013·Journal of Atherosclerosis and Thrombosis·Hiromi SaitoMichitaka Naito
Jan 23, 2018·Journal of Atherosclerosis and Thrombosis·Akihiro NomuraMasakazu Yamagishi
Dec 14, 2012·The American Journal of Clinical Nutrition·Cécile VorsMarie-Caroline Michalski
Dec 4, 2020·Journal of Applied Physiology·Stephanie MuntenDominique D Gagnon
Jul 12, 2011·Current Opinion in Lipidology

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