Delayed postprandial TAG peak after intake of SFA compared with PUFA in subjects with and without familial hypercholesterolaemia: a randomised controlled trial

The British Journal of Nutrition
Linn K L ØyriKirsten B Holven

Abstract

Postprandial hypertriacylglycerolaemia is associated with an increased risk of developing CVD. How fat quality influences postprandial lipid response is scarcely explored in subjects with familial hypercholesterolaemia (FH). The aim of this study was to investigate the postprandial response of TAG and lipid sub-classes after consumption of high-fat meals with different fat quality in subjects with FH compared with normolipidaemic controls. A randomised controlled double-blind cross-over study with two meals and two groups was performed. A total of thirteen hypercholesterolaemic subjects with FH who discontinued lipid-lowering treatment 4 weeks before and during the study, and fourteen normolipidaemic controls, were included. Subjects were aged 18-30 years and had a BMI of 18·5-30·0 kg/m2. Each meal consisted of a muffin containing 60 g (70 E%) of fat, either mainly SFA (40 E%) or PUFA (40 E%), eaten in a random order with a wash-out period of 3-5 weeks between the meals. Blood samples were collected at baseline (fasting) and 2, 4 and 6 h after intake of the meals. In both FH and control subjects, the level of TAG and the largest VLDL sub-classes peaked at 2 h after intake of PUFA and at 4 h after intake of SFA. No significant d...Continue Reading

References

Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
Jul 17, 1995·Biochemical and Biophysical Research Communications·A J BennettD A White
Jan 1, 1997·The British Journal of Nutrition·S W SakrA Girard-Globa
Jul 3, 1998·European Journal of Clinical Investigation·J C MamoA Yamamoto
Feb 13, 2001·European Journal of Clinical Investigation·C A Dane-StewartT G Redgrave
Apr 18, 2003·Metabolism: Clinical and Experimental·Darby S Petitt, Kirk J Cureton
Oct 4, 2003·Current Atherosclerosis Reports·Dianne HysonLars Berglund
Jan 30, 2004·Biochemical Society Transactions·C M WilliamsP Yaqoob
Jan 8, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·John S MillarDaniel J Rader
Jun 9, 2007·The American Journal of Clinical Nutrition·Sarah E E BerryThomas A B Sanders
Aug 28, 2007·The American Journal of Cardiology·James H O'Keefe, David S H Bell
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mark J DekkerLindsay E Robinson
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Nov 12, 2009·JAMA : the Journal of the American Medical Association·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
Mar 9, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Robert W SchwenkJan F C Glatz
Sep 10, 2010·International Journal of Cardiology·Genovefa D KolovouKatherine K Anagnostopoulou
Apr 20, 2011·Circulation·Michael MillerUNKNOWN Council on the Kidney in Cardiovascular Disease
May 3, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katsuyuki NakajimaAkira Tanaka
Sep 29, 2011·Metabolism: Clinical and Experimental·Dick C Chan, Gerald F Watts
Feb 15, 2012·Journal of the American College of Nutrition·Tilakavati KarupaiahKalyana Sundram
Jul 20, 2012·Journal of Lipid Research·Gilles LambertG Kees Hovingh
Aug 14, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Indra Ramasamy
Sep 7, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ryan L McKimmieRichard B Weinberg
Apr 12, 2014·Biochimica Et Biophysica Acta·Sander Kersten

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.