Delayed rectifier potassium channels are involved in SO2 derivative-induced hippocampal neuronal injury

Ecotoxicology and Environmental Safety
Guangke Li, Nan Sang

Abstract

Recent studies implicate the possible neurotoxicity of SO(2), however, its mechanisms remain unclear. In the present study, we investigated SO(2) derivative-induced effect on delayed rectifier potassium channels (I(K)) and cellular death/apoptosis in primary cultured hippocampal neurons. The results demonstrate that SO(2) derivatives (NaHSO(3) and Na(2)SO(3), 3:1M/M) effectively augmented I(K) and promoted the activation of delayed rectifier potassium channels. Also, SO(2) derivatives increased neuronal death percentage and contributed to the formation of DNA ladder in concentration-dependent manners. Interestingly, the neuronal death and DNA ladder formation, caused by SO(2) derivatives, could be attenuated by the delayed rectifier potassium channel blocker (tetraethylammonium, TEA), but not by the transient outward potassium channel blocker (4-aminopyridine, 4-AP). It implies that stimulating delayed rectifier potassium channels were involved in SO(2) derivative-caused hippocampal neuronal insults, and blocking these channels might be one of the possibly clinical treatment for SO(2)-caused neuronal dysfunction.

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Citations

Jan 20, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nan SangGuangke Li
Aug 30, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nan SangGuang-ke Li
Jun 2, 2017·Luminescence : the Journal of Biological and Chemical Luminescence·Yun ZhangJuan Zhang
Feb 7, 2020·Organic & Biomolecular Chemistry·Xiaojing HanYong Ye
Nov 7, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Xingyu TongYong Shao
Jun 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yingzhong ZhuYupeng Tian
May 23, 2014·Organic & Biomolecular Chemistry·Li TanKaibo Zheng
Apr 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ming-Yu WuXiao-Qi Yu
Dec 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hridesh AgarwallaAmitava Das
Feb 26, 2013·Chemical Communications : Chem Comm·Yuan-Qiang SunWei Guo
Feb 4, 2019·Environmental Science and Pollution Research International·Shuyue LiNan Sang
Feb 5, 2015·Chemical Reviews·Xin ZhouJuyoung Yoon

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