Abstract
A recent pilot study suggested that exercise-induced myocardial ischaemia may lead to a delayed release of cardiac biomarkers, so that later sampling, for example, at 4 h after exercise could be used for diagnostic purpose. In an observational study, we enrolled 129 consecutive patients referred for evaluation of a suspected coronary artery disease by rest/stress myocardial perfusion single-photon emission computed tomography. The treating cardiologist used all available clinical information to quantify clinical judgment regarding the presence of myocardial ischaemia using a visual analogue scale twice: prior and after stress testing. BNP levels were determined in a blinded fashion at rest, at peak stress and 4 h after peak stress. The presence of myocardial ischaemia was adjudicated based on perfusion single-photon emission computed tomography and coronary angiography findings by an independent cardiologist. Myocardial ischaemia was detected in 58 patients (45%). Patients with myocardial ischaemia had significantly higher BNP levels at all times, compared to patients without ischaemia: BNP rest (99 vs. 61 pg/mL P = 0·007), BNP stress (125 vs. 77 pg/mL P = 0·02) and BNP 4 h (114 vs. 71 pg/mL P = 0·018). Diagnostic accuracy as q...Continue Reading
References
Jul 1, 1989·Circulation·R GianrossiV Froelicher
Nov 1, 1993·Journal of the American College of Cardiology·D S BermanG Germano
Jan 30, 2002·Circulation·Manuel D CerqueiraUNKNOWN American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging
Apr 24, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J P GoetzeL B Nielsen
Nov 16, 2004·Journal of the American College of Cardiology·Robert S FooteKiang-Teck J Yeo
Nov 16, 2004·Journal of the American College of Cardiology·Marc S SabatineEugene Braunwald
Nov 8, 2005·The American Journal of Medicine·Daniel StaubChristian Mueller
Jul 19, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Elena BiaginiJeroen J Bax
Mar 4, 2008·Clinical Chemistry·Kristin N LuckenbillFred S Apple
Mar 4, 2008·Journal of Clinical Epidemiology·Erik von ElmUNKNOWN STROBE Initiative
Nov 11, 2008·European Heart Journal·Marc S SabatineEugene Braunwald
Nov 10, 2009·International Journal of Cardiology·Micha T MaederChristian Mueller
Feb 5, 2011·European Heart Journal·Kristian ThygesenUNKNOWN Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care
Nov 15, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Gary Nichols
Mar 9, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yuan XuPiotr J Slomka
Oct 24, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mario PetrettaAlberto Cuocolo
Nov 28, 2012·Journal of the American College of Cardiology·Stephan D FihnUNKNOWN Society of Thoracic Surgeons
Feb 4, 2014·The American Journal of Medicine·Gino LeeChristian Mueller
Jun 27, 2015·Journal of Clinical Epidemiology·Richard G WhiteWolfgang Hladik
Citations
Mar 30, 2019·European Journal of Clinical Investigation·Ursina HoneggerChristian Mueller
Jun 22, 2019·European Journal of Heart Failure·Christian MuellerUNKNOWN Heart Failure Association of the European Society of Cardiology
Oct 19, 2017·Clinical Chemistry·Joan E WalterChristian Mueller
Jan 7, 2020·Annals of Internal Medicine·Joan WalterChristian Mueller
Jul 26, 2016·Experimental and Therapeutic Medicine·Lu GanLi Yang
Nov 7, 2017·Clinical Biochemistry·Christian PuelacherChristian Mueller