Jan 1, 1989

Delayed response of the mouse uterus to progesterone and oestradiol

Reproduction, Fertility, and Development
C M Murray, G M Stone

Abstract

The delayed response of the uterus of the ovariectomized mouse to progesterone (P) required the presence of a low dose of oestradiol-17 beta (E2) and was associated with a maintained level of uterine DNA, an increase in RNA:DNA ratio and in total tissue protein and a decreased level of uterine P. This last parameter was associated with an increased level of in vitro metabolism of P by the uterus. Changes in the level of receptors for P and E2 were temporally unrelated to the delayed response. Omission of oestradiol every second, third or fourth day inhibited development of the delayed response, which could also be obtained with the long acting progestogen, medroxy progesterone acetate, and E2 or oestradiol benzoate.

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Mentioned in this Paper

Metabolic Process, Cellular
Entire Uterus
Progesterone, (9 beta,10 alpha)-Isomer
Neoplasm of Uncertain or Unknown Behavior of Uterus
Uterus
Estradiol, (16 alpha,17 beta)-Isomer
Estradiol Measurement
Progesterone
Total Tissue
Progesterone [EPC]

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