Delayed Rise of Oral Fluid Antibodies, Elevated BMI, and Absence of Early Fever Correlate With Longer Time to SARS-CoV-2 RNA Clearance in a Longitudinally Sampled Cohort of COVID-19 Outpatients.

Open Forum Infectious Diseases
Annukka A R AntarYukari C Manabe

Abstract

Sustained molecular detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the upper respiratory tract (URT) in mild to moderate coronavirus disease 2019 (COVID-19) is common. We sought to identify host and immune determinants of prolonged SARS-CoV-2 RNA detection. Ninety-five symptomatic outpatients self-collected midturbinate nasal, oropharyngeal (OP), and gingival crevicular fluid (oral fluid) samples at home and in a research clinic a median of 6 times over 1-3 months. Samples were tested for viral RNA, virus culture, and SARS-CoV-2 and other human coronavirus antibodies, and associations were estimated using Cox proportional hazards models. Viral RNA clearance, as measured by SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR), in 507 URT samples occurred a median (interquartile range) 33.5 (17-63.5) days post-symptom onset. Sixteen nasal-OP samples collected 2-11 days post-symptom onset were virus culture positive out of 183 RT-PCR-positive samples tested. All participants but 1 with positive virus culture were negative for concomitant oral fluid anti-SARS-CoV-2 antibodies. The mean time to first antibody detection in oral fluid was 8-13 days post-symptom onset. A longer time to f...Continue Reading

References

Sep 2, 2008·Virology·Scott R SchaecherAndrew Pekosz
Dec 23, 2017·Frontiers in Immunology·Daniela FrascaRoberto Paganelli
Mar 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Shutoku MatsuyamaMakoto Takeda
May 20, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jason J LeBlancGlenn Patriquin
Jun 4, 2020·The New England Journal of Medicine·Yuan-Po TuEthan M Berke
Aug 9, 2020·The Journal of Clinical Investigation·Sabra L KleinAaron Ar Tobian
Aug 29, 2020·The New England Journal of Medicine·Anne L WyllieAlbert I Ko
Sep 15, 2020·Frontiers in Endocrinology·Karina Colombera PeresLucas Leite Cunha
Oct 18, 2020·Journal of Clinical Microbiology·Nora PisanicChristopher D Heaney
Oct 23, 2020·The Journal of Infectious Diseases·Ji Hoon BaangAdam S Lauring
Dec 2, 2020·The New England Journal of Medicine·Teresa AydilloMini Kamboj
Dec 18, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yukiko NakajimaNobuhiko Okabe
Jan 20, 2021·Annals of the Academy of Medicine, Singapore·Jamie S Y HoChing Hui Sia

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