PMID: 16648902May 2, 2006Paper

Delayed Schwann cell and oligodendrocyte remyelination after ethidium bromide injection in the brainstem of Wistar rats submitted to streptozotocin diabetogenic treatment

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Eduardo Fernandes BondanDominguita Lühers Graça

Abstract

Schwann cell disturbance followed by segmental demyelination in the peripheral nervous system occurs in diabetic patients. Since Schwann cell and oligodendrocyte remyelination in the central nervous system is a well-known event in the ethidium bromide (EB) demyelinating model, the aim of this investigation was to determine the behavior of both cell types after local EB injection into the brainstem of streptozotocin diabetic rats. Adult male Wistar rats received a single intravenous injection of streptozotocin (50 mg/kg) and were submitted 10 days later to a single injection of 10 microL 0.1% (w/v) EB or 0.9% saline solution into the cisterna pontis. Ten microliters of 0.1% EB was also injected into non-diabetic rats. The animals were anesthetized and perfused through the heart 7 to 31 days after EB or saline injection and brainstem sections were collected and processed for light and transmission electron microscopy. The final balance of myelin repair in diabetic and non-diabetic rats at 31 days was compared using a semi-quantitative method. Diabetic rats presented delayed macrophage activity and lesser remyelination compared to non-diabetic rats. Although oligodendrocytes were the major remyelinating cells in the brainstem, Sch...Continue Reading

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Citations

Sep 12, 2006·Visual Neuroscience·Bruno D GomesManoel da Silva Filho
Oct 9, 2009·Experimental Diabetes Research·Juan P Hernández-FonsecaJesús Mosquera
Jul 16, 2008·Medical Hypotheses·Xiaoming GongHuancong Zuo
Apr 25, 2013·Microscopy Research and Technique·Eduardo Fernandes Bondan, Maria De Fátima Monteiro Martins
Nov 5, 2013·Microscopy Research and Technique·Eduardo Fernandes BondanMaria Martha Bernardi
Nov 15, 2011·The American Journal of Pathology·Diego C FernandezRuth E Rosenstein
May 1, 2015·Archives of Endocrinology and Metabolism·Eduardo Fernandes BondanMaria Martha Bernardi
Sep 14, 2013·Arquivos brasileiros de endocrinologia e metabologia·Eduardo Fernandes BondanFlávio Cesar Viani
Nov 5, 2010·Arquivos de neuro-psiquiatria·Eduardo Fernandes BondanDominguita Luhers Graça
Jun 1, 2011·Arquivos de neuro-psiquiatria·Eduardo Fernandes BondanMaria Anete Lallo
Jan 14, 2010·Arquivos de neuro-psiquiatria·Eduardo Fernandes BondanDominguita Luhers Graça
Jul 22, 2008·Arquivos de neuro-psiquiatria·Eduardo Fernandes BondanDominguita Lühers Graça
Mar 7, 2012·Arquivos de neuro-psiquiatria·Eduardo Fernandes Bondan, Maria de Fátima Monteiro Martins
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saiedeh Arabmoazzen, Mohammad Ali Mirshekar

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