Delayed Spine Pruning of Direct Pathway Spiny Projection Neurons in a Mouse Model of Parkinson's Disease

Frontiers in Cellular Neuroscience
Steven M Graves, D James Surmeier

Abstract

In animal models of Parkinson's disease (PD), principal striatal spiny projection neurons (SPNs) lose axospinous synapses. However, there has been a disagreement about whether this loss is restricted to a specific type of SPN or not, as some studies have reported pruning in both direct pathway SPNs and indirect pathway SPNs, while others have found this pruning to be restricted to indirect pathway SPNs. One possible explanation for the discrepancy is the period between the induction of the parkinsonian state and the assessment of spine loss. To test this hypothesis, transgenic mice were subjected to unilateral 6-hydroxydopamine (6-OHDA) lesions of nigrostriatal dopaminergic neurons and then direct pathway SPNs examined in ex vivo brain slices using two photon laser scanning microscopy either one or 2 months afterwards. These studies revealed that 1 month after the lesion, there was no loss of spines in direct pathway SPNs. However, 2 months after the lesion, spine loss was significant in direct pathway SPNs. In addition to reconciling the existing literature on the impact of the parkinsonian state on axospinous synapse elimination in SPNs, our results suggest that the delayed spine loss in direct pathway SPNs is not driven by h...Continue Reading

References

Jun 23, 2006·Nature Reviews. Neuroscience·Eve Marder, Jean-Marc Goaillard
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Citations

Jul 10, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Luz M SuarezRosario Moratalla
Jul 1, 2020·The European Journal of Neuroscience·Ida Luisa BoccalaroLena Rubi
May 13, 2020·The European Journal of Neuroscience·Ivan Castela, Ledia F Hernandez
Mar 1, 2020·Acta Pharmacologica Sinica·Hong-Yuan Chu
Oct 2, 2020·Nature·Ana BadimonAnne Schaefer
Apr 2, 2019·Frontiers in Neural Circuits·Yijuan Du, Steven M Graves
Apr 3, 2019·Journal of Neural Transmission·Shenyu ZhaiD James Surmeier
Mar 20, 2021·Frontiers in Cellular Neuroscience·Nolwazi Z GcwensaLaura A Volpicelli-Daley
Jun 1, 2021·Frontiers in Aging Neuroscience·Haruo NishijimaMasahiko Tomiyama

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Methods Mentioned

BETA
Scanning Microscopy

Software Mentioned

GraphPad Prism
AutoQuant
GraphPad
2PLSM
NeuronStudio

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