Delayed timing of post-challenge peak blood glucose predicts declining beta cell function and worsening glucose tolerance over time: insight from the first year postpartum

Diabetologia
Caroline K KramerRavi Retnakaran

Abstract

On cross-sectional assessment, a delayed timing of the peak blood glucose level at ≥60 min post-challenge on an OGTT is associated with beta cell dysfunction. In this context, we hypothesised that longitudinal changes in the timing of this peak might predict changes in glucose metabolism. We thus sought to evaluate the longitudinal associations of changes in the timing of the peak glucose level with changes over time in insulin sensitivity, beta cell function and glucose tolerance. A total of 532 women underwent an OGTT at both 3 months and 12 months postpartum. The participants were stratified into four groups according to the change in timing of their glucose peak between the two visits: women with no change in timing of the glucose peak at 30 min (n = 217), those whose glucose peak shifted to an earlier time point (n = 120), those whose peak shifted to a later time point (n = 87) and women with an unchanged glucose peak at ≥60 min (n = 108). Beta cell function was measured using the Insulin Secretion-Sensitivity Index-2 (ISSI-2). Compared with an unchanged glucose peak at 30 min, both the shift of the glucose peak to a later time point and a peak that was unchanged at ≥60 min were independently associated with declining ISSI...Continue Reading

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Citations

Jul 7, 2017·Clinical Endocrinology·Stephanie T ChungAnne E Sumner
Dec 1, 2017·American Journal of Physiology. Endocrinology and Metabolism·Susan TranRavi Retnakaran
Jan 24, 2020·The Journal of Clinical Endocrinology and Metabolism·Alfonso GalderisiSonia Caprio
Jun 27, 2018·Journal of the Endocrine Society·Melanie Cree-GreenKristen J Nadeau

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