Delayed treatment of MS is associated with high CSF levels of IL-6 and IL-8 and worse future disease course

Journal of Neurology
Mario Stampanoni BassiFabio Buttari

Abstract

Clinical deterioration of relapsing-remitting MS (RR-MS) patients reflects not only the number and severity of overt inflammatory and demyelinating episodes, but also subtle central damage caused by persistent exposure to inflammatory molecules. To explore the correlation between levels of CSF inflammatory molecules at the time of diagnosis and both demographic and clinical characteristics of a large sample of RR-MS patients, as well as the predictive value of cytokine levels on their prospective disease course. In 205 patients diagnosed with RR-MS, we measured at the time of diagnosis the CSF levels of inflammatory molecules. Clinical and MRI evaluation was collected at the time of CSF withdrawal and during a median follow-up of 3 years. The time interval between the first anamnestic episode of focal neurological dysfunction and RR-MS diagnosis was the main factor associated with high CSF levels of IL-6 and IL-8. Furthermore, elevated CSF levels of these cytokines correlated with enhanced risk of clinical and radiological disease reactivation, switch to second-line treatments, and with disability progression in the follow-up. Delayed diagnosis and treatment initiation are associated with higher CSF levels of IL-6 and IL-8 in R...Continue Reading

References

Feb 27, 1997·Journal of the Neurological Sciences·D MaimoneP Annunziata
May 30, 2001·Lancet·G ComiUNKNOWN Early Treatment of Multiple Sclerosis Study Group
Mar 4, 2005·Brain : a Journal of Neurology·Takaaki IshizuJun-ichi Kira
Jun 14, 2005·Journal of the Neurological Sciences·Ralf A LinkerRalf Gold
Jan 24, 2006·Lancet Neurology·Robert A Bermel, Rohit Bakshi
Sep 20, 2006·Journal of Neuroimmunology·Suhayl Dhib-JalbutV Wee Yong
May 4, 2007·The Journal of Clinical Investigation·Ilona Gutcher, Burkhard Becher
Dec 7, 2007·Brain : a Journal of Neurology·Thomas ZeisNicole Schaeren-Wiemers
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diego CentonzeGianvito Martino
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Oct 26, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Sabine SkrzipekAlexander Dressel
Jan 26, 2012·Annals of Neurology·Silvia RossiDiego Centonze
Jul 19, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Georgia MandolesiDiego Centonze
Jul 28, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Silvia RossiDiego Centonze
Jan 22, 2014·CNS Drugs·Nicola De StefanoBernd C Kieseier
Jan 15, 2015·Multiple Sclerosis : Clinical and Laboratory Research·S RossiD Centonze
Aug 12, 2016·Neurology·Ludwig KapposUNKNOWN BENEFIT Study Group
Aug 28, 2016·Journal of Neuroinflammation·Antonietta GentileDiego Centonze
May 17, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mario Stampanoni BassiEnnio Iezzi
Jun 18, 2017·Multiple Sclerosis and Related Disorders·Z MatejčíkováP Kaňovský
Dec 26, 2017·Lancet Neurology·Alan J ThompsonJeffrey A Cohen
Jan 7, 2018·Journal of Neuroinflammation·Antonietta GentileGeorgia Mandolesi

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Citations

Jun 5, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Mario Stampanoni BassiGiuseppe Matarese
Aug 23, 2019·Neurorehabilitation and Neural Repair·Mario Stampanoni BassiFrancesca Romana Rizzo
Jul 14, 2020·Frontiers in Cellular Neuroscience·Mario Stampanoni BassiFabio Buttari
Dec 28, 2019·International Journal of Molecular Sciences·Mario Stampanoni BassiFabio Buttari
Sep 5, 2019·Cellular and Molecular Neurobiology·Meysam Moghbeli
Jan 7, 2021·Metabolic Brain Disease·Soudeh Ghafouri-FardMohammad Taheri
Dec 22, 2020·Therapeutic Advances in Neurological Disorders·Mario Stampanoni BassiFabio Buttari

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