Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model

Stroke; a Journal of Cerebral Circulation
D A PhillipsR H Pang

Abstract

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are under way. We evaluated two fibrinolytic agents, an analogue of tissue plasminogen activator (Fb-Fb-CF, the catalytic fragment of the tissue plasminogen activator molecule with a prolonged serum half-life, n = 10) and streptokinase (n = 7), in a rabbit model of embolic stroke. Both agents were given 3 hours after stroke onset, a time relevant to the clinical setting. Fb-Fb-CF was significantly better (p less than 0.04) than saline (n = 7) in restoring blood flow to previously occluded intracranial arteries, but streptokinase was ineffective. Neither fibrinolytic agent was associated with a substantial risk for intracerebral hemorrhagic side effects. Our study demonstrates that Fb-Fb-CF can safely and effectively reperfuse rabbit intracranial arteries 3 hours after occlusion, while streptokinase does not.

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Citations

Jan 1, 1995·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·S M ZhangR C Heros
Feb 21, 2002·Neurologic Clinics·B T Volpe
Jul 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·K OvergaardN H Diemer
Jan 1, 1992·Progress in Cardiovascular Diseases·S R Levine, T G Brott
May 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K OvergaardG Boysen
Feb 1, 1996·Italian Journal of Neurological Sciences·L CandeliseA P Maggioni

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