Abstract
Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are under way. We evaluated two fibrinolytic agents, an analogue of tissue plasminogen activator (Fb-Fb-CF, the catalytic fragment of the tissue plasminogen activator molecule with a prolonged serum half-life, n = 10) and streptokinase (n = 7), in a rabbit model of embolic stroke. Both agents were given 3 hours after stroke onset, a time relevant to the clinical setting. Fb-Fb-CF was significantly better (p less than 0.04) than saline (n = 7) in restoring blood flow to previously occluded intracranial arteries, but streptokinase was ineffective. Neither fibrinolytic agent was associated with a substantial risk for intracerebral hemorrhagic side effects. Our study demonstrates that Fb-Fb-CF can safely and effectively reperfuse rabbit intracranial arteries 3 hours after occlusion, while streptokinase does not.
References
Jan 1, 1990·Annals of Internal Medicine·C S KaseJ I Ordia
Mar 1, 1989·Annals of Neurology·D A PhillipsR H Pang
Feb 1, 1989·Chest·J A CairnsE R Passamani
Dec 1, 1988·Journal of the American College of Cardiology
Dec 1, 1988·Annals of Neurology·R N Auer, B K Siesjö
Feb 1, 1986·Circulation·H K GoldD Collen
Nov 1, 1987·Journal of the American College of Cardiology·D Collen
Apr 1, 1988·Archives of Neurology·J A ZivinP Johnston
Apr 1, 1988·Annals of Neurology·D A PhillipsM A Davis
Oct 1, 1988·Stroke; a Journal of Cerebral Circulation·W HackeG J del Zoppo
Jul 1, 1987·Archives of Neurology·M A Sloan
Jul 1, 1988·Archives of Internal Medicine·R C Becker, J S Alpert
Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·G J Del ZoppoL A Harker
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
Apr 1, 1957·Acta Haematologica·A CLAUSS
Citations
Jan 1, 1995·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·S M ZhangR C Heros
Nov 1, 1993·Journal of the Neurological Sciences·P MedenG Boysen
Feb 21, 2002·Neurologic Clinics·B T Volpe
Mar 6, 2009·Journal of Human Hypertension·A MilanF Veglio
May 14, 1998·Epilepsia·A StefaniG Bernardi
Oct 1, 1996·Journal of Neurosurgery·X Di, R Bullock
Jul 7, 2000·Journal of Neurosurgery·R B MasonR J Boock
Jul 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·K OvergaardN H Diemer
Jan 1, 1992·Progress in Cardiovascular Diseases·S R Levine, T G Brott
May 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K OvergaardG Boysen
Oct 24, 2002·Investigative Radiology·Karsten Krueger, Elmar Busch
Feb 1, 1996·Italian Journal of Neurological Sciences·L CandeliseA P Maggioni